Effect of Non-surgical Periodontal Treatment on Cardiovascular Risk Markers
NCT ID: NCT04305171
Last Updated: 2020-03-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
28 participants
OBSERVATIONAL
2018-04-06
2020-02-20
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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coronary heart disease patients with periodontitis
Coronary heart disease patients confirmed through coronary angiography as having at least 50% diameter stenosis in at least one coronary artery and clinically stable with the absence of any potentially confounding inflammatory conditions for at least 6 months.
Periodontitis classified as havingbleeding on probing (BOP), pocket depth (PD) \> 4 mm, clinical attachment level (CAL) ≥ 5 mm and radiographic evidence of bone loss were presented at the same site of at least 4 teeth.
non-surgical periodontal treatment
scaling and root planing, home care instruction
coronary heart disease patients without periodontitisHD
Coronary heart disease patients confirmed through coronary angiography as having at least 50% diameter stenosis in at least one coronary artery and clinically stable with the absence of any potentially confounding inflammatory conditions for at least 6 months.
Non-periodontitis classified as having PD ≤ 3 mm.
non-surgical periodontal treatment
scaling and root planing, home care instruction
non-coronary heart disease patients with periodontitis
Periodontitis classified as havingbleeding on probing (BOP), pocket depth (PD) \> 4 mm, clinical attachment level (CAL) ≥ 5 mm and radiographic evidence of bone loss were presented at the same site of at least 4 teeth.
non-surgical periodontal treatment
scaling and root planing, home care instruction
non-coronary heart disease patients without periodontitis
Non-periodontitis classified as having PD ≤ 3 mm.
non-surgical periodontal treatment
scaling and root planing, home care instruction
Interventions
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non-surgical periodontal treatment
scaling and root planing, home care instruction
Eligibility Criteria
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Inclusion Criteria
* had at least 14 natural teeth excluding third molars
Exclusion Criteria
* had chronic conditions (e.g. diabetes mellitus, rheumatoid arthritis, malignancy, autoimmune disease) or acute conditions (e.g. trauma, surgery) or medications known to affect systemic inflammatory markers (e.g. antibiotics, immunosuppressive, contraceptives) within 3 months
* pregnancy or lactation
* presence or history of other infections
* periodontal treatment within 6 months
* tooth extractions within 2 months prior to the study.
35 Years
70 Years
ALL
Yes
Sponsors
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Mahidol University
OTHER
Responsible Party
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Principal Investigators
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Supanee Rassameemasmaung, PhD
Role: PRINCIPAL_INVESTIGATOR
Mahidol University Faculty of Dentistry
Locations
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Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University
Ratchathewi, Bangkok, Thailand
Department of Medicine, Rajavithi Hospital
Ratchathewi, Bangkok, Thailand
Mahidol University Faculty of Dentistry
Ratchathewi, Bangkok, Thailand
Countries
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References
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Ye Z, Cao Y, Miao C, Liu W, Dong L, Lv Z, Iheozor-Ejiofor Z, Li C. Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis. Cochrane Database Syst Rev. 2022 Oct 4;10(10):CD009197. doi: 10.1002/14651858.CD009197.pub5.
Other Identifiers
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MU-DT/PY-IRB 2018/022.0504
Identifier Type: -
Identifier Source: org_study_id
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