Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
93 participants
INTERVENTIONAL
2012-01-31
2017-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
SINGLE
Study Groups
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Comprehensive treatment
Test treatment group
Subgingival scaling and root planing
Oral hygiene instruction and motivation will be provided altogether with scaling and root planing of all teeth affected by periodontitis under local anesthesia
Community treatment
Control treatment group
Oral prophylaxis
One session of supraginigval calculus removal
Interventions
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Subgingival scaling and root planing
Oral hygiene instruction and motivation will be provided altogether with scaling and root planing of all teeth affected by periodontitis under local anesthesia
Oral prophylaxis
One session of supraginigval calculus removal
Eligibility Criteria
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Inclusion Criteria
* coronary artery disease
* more than 10 teeth
* chronic periodontitis defined as 2 non-adjacent teeth with probing depth 5+mm and periodontal attachment loss 4+mm
Exclusion Criteria
* periodontal therapy in the last 12 months
35 Years
70 Years
ALL
No
Sponsors
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Federal University of Rio Grande do Sul
OTHER
Responsible Party
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Alex Nogueira Haas
Professor
Principal Investigators
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Alex N Haas, PhD
Role: STUDY_CHAIR
Federal University of Rio Grande do Sul, Periodontology
Cassiano K Rosing, PhD
Role: STUDY_CHAIR
Federal University of Rio Grande do Sul, Periodontology
Carisi Polanczyk, PhD
Role: STUDY_CHAIR
Federal University of Rio Grande do Sul, Cardiology
Eneida RR Rabelo da Silva, PhD
Role: STUDY_CHAIR
Federal University of Rio Grande do Sul
Marco A Saffi, MS
Role: PRINCIPAL_INVESTIGATOR
Federal University of Rio Grande do Sul, Cardiology
Cassio Kampits, MS
Role: PRINCIPAL_INVESTIGATOR
Federal University of Rio Grande do Sul, Periodontology
Ingrid Sanada, MS
Role: PRINCIPAL_INVESTIGATOR
Federal University of Rio Grande do Sul, Periodontology
Marlon Montenegro, MS
Role: PRINCIPAL_INVESTIGATOR
Federal University of Rio Grande do Sul, Periodontology
Mariana V Furtado, MS
Role: STUDY_DIRECTOR
Federal University of Rio Grande do Sul, Cardiology
Locations
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Federal University of Rio Grande do Sul, School of Dentistry and University Hospital
Porto Alegre, Rio Grande do Sul, Brazil
Countries
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References
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Ramirez JH, Arce RM, Contreras A. Periodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial. Trials. 2011 Feb 16;12:46. doi: 10.1186/1745-6215-12-46.
Paraskevas S, Huizinga JD, Loos BG. A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. J Clin Periodontol. 2008 Apr;35(4):277-90. doi: 10.1111/j.1600-051X.2007.01173.x. Epub 2008 Feb 20.
Blaizot A, Vergnes JN, Nuwwareh S, Amar J, Sixou M. Periodontal diseases and cardiovascular events: meta-analysis of observational studies. Int Dent J. 2009 Aug;59(4):197-209.
Lockhart PB, Bolger AF, Papapanou PN, Osinbowale O, Trevisan M, Levison ME, Taubert KA, Newburger JW, Gornik HL, Gewitz MH, Wilson WR, Smith SC Jr, Baddour LM; American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young, Council on Epidemiology and Prevention, Council on Peripheral Vascular Disease, and Council on Clinical Cardiology. Periodontal disease and atherosclerotic vascular disease: does the evidence support an independent association?: a scientific statement from the American Heart Association. Circulation. 2012 May 22;125(20):2520-44. doi: 10.1161/CIR.0b013e31825719f3. Epub 2012 Apr 18.
Montenegro MM, Ribeiro IWJ, Kampits C, Saffi MAL, Furtado MV, Polanczyk CA, Haas AN, Rosing CK. Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable coronary artery disease: Preliminary findings of 3 months. J Clin Periodontol. 2019 Mar;46(3):321-331. doi: 10.1111/jcpe.13085. Epub 2019 Mar 6.
Saffi MA, Furtado MV, Montenegro MM, Ribeiro IW, Kampits C, Rabelo-Silva ER, Polanczyk CA, Rosing CK, Haas AN. The effect of periodontal therapy on C-reactive protein, endothelial function, lipids and proinflammatory biomarkers in patients with stable coronary artery disease: study protocol for a randomized controlled trial. Trials. 2013 Sep 6;14:283. doi: 10.1186/1745-6215-14-283.
Related Links
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School of Dentistry homepage
University Hospital homepage
Other Identifiers
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HCPA110146
Identifier Type: -
Identifier Source: org_study_id
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