Study Results
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Basic Information
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COMPLETED
960 participants
OBSERVATIONAL
2009-10-31
2012-05-31
Brief Summary
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The hypothesis of this study is that periodontitis is a prognostic relevant risk factor for patients with angiographically proven coronary heart disease. Furthermore, the infectious pathogen burden by PCR-detection of periodontal pathogens will be evaluated as a prognostic factor.
960 consecutive patients with angiographically proven coronary heart disease will be included in this study. After inclusion of patients an extensive periodontal examination including PCR-sampling for 11 bacteria (Porphyromonas gingivitis, Actinobacillus actinomycetemcomitans, and others) will be performed. After 12 months patient will be follow up for any major adverse events (cardiovascular death, myocardial infarction, stroke).
If this study will find a relation of periodontitis or its microbiological agents to cardiovascular outcome of patients with coronary heart disease, further studies are necessary to investigate potential therapeutic consequences for patients with CHD and periodontitis.
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Detailed Description
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Conditions
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Study Design
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PROSPECTIVE
Study Groups
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coronary heart disease
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Coronary heart disease as defined by previous or current detection of 50% stenosis of a main coronary artery by coronary angiography or previous or current percutaneous coronary intervention (PCI) or previous or current coronary artery bypass surgery (CABG)
Exclusion Criteria
* Periodontal treatment and/or antibiotic therapy during the last 6 months
* Pregnancy
* Current alcohol or drug abuse, or psychological reasons that make study participation impractical
* Drugs which are potential causal for gingival hyperplasia (Hydantoin, Nifedipine, Cyclosporin A, and other)
18 Years
ALL
No
Sponsors
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The German Heart Foundation
OTHER
Martin-Luther-Universität Halle-Wittenberg
OTHER
Responsible Party
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Axel Schlitt
PD Dr. med. habil.
Principal Investigators
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Axel Schlitt, MD
Role: PRINCIPAL_INVESTIGATOR
Department of Medicine III, Martin Luther-University Halle-Wittenberg
Locations
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Martin Luther-University Halle-Wittenberg
Halle, , Germany
Countries
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References
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Reichert S, Rehm S, Schlitt A, Schulz S. Severe Periodontitis is Associated With Recurrent Cardiovascular Events-A 10-Year Longitudinal Cohort Study. J Periodontal Res. 2024 Nov 22. doi: 10.1111/jre.13365. Online ahead of print.
Schulz S, Rehm S, Schlitt A, Bitter K, Reichert S. The Interleukin 6 Protein Level as well as a Genetic Variants, (rs1800795, rs1800797) Are Associated with Adverse Cardiovascular Outcomes within 10-Years Follow-Up. Cells. 2023 Nov 28;12(23):2722. doi: 10.3390/cells12232722.
Schulz S, Rehm S, Schlitt A, Lierath M, Ludike H, Hofmann B, Bitter K, Reichert S. C-Reactive Protein Level and the Genetic Variant rs1130864 in the CRP Gene as Prognostic Factors for 10-Year Cardiovascular Outcome. Cells. 2023 Jul 4;12(13):1775. doi: 10.3390/cells12131775.
Schulz S, Zielske M, Schneider S, Hofmann B, Schaller HG, Schlitt A, Reichert S. Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease. Mediators Inflamm. 2021 Jul 8;2021:3002439. doi: 10.1155/2021/3002439. eCollection 2021.
Reichert S, Seitter L, Schaller HG, Schlitt A, Schulz S. ANRIL polymorphisms (rs1333049 and rs3217992) in relation to plasma CRP levels among in-patients with CHD. Cytokine. 2020 Mar;127:154932. doi: 10.1016/j.cyto.2019.154932. Epub 2019 Nov 27.
Schulz S, Schlitt A, Hofmann B, Schaller HG, Reichert S. Periodontal pathogens and their role in cardiovascular outcome. J Clin Periodontol. 2020 Feb;47(2):173-181. doi: 10.1111/jcpe.13224. Epub 2019 Dec 16.
Reichert S, Schlitt A, Benten AC, Hofmann B, Schaller HG, Schulz S. Data on IL-6 c.-174 G>C genotype and allele frequencies in patients with coronary heart disease in dependence of cardiovascular outcome. Data Brief. 2016 Jul 16;8:1295-9. doi: 10.1016/j.dib.2016.07.020. eCollection 2016 Sep.
Schulz S, Schlitt A, Lutze A, Lischewski S, Seifert T, Dudakliewa T, Gawe R, Werdan K, Hofmann B, Glaser C, Schaller HG, Reichert S. The importance of genetic variants in TNFalpha for periodontal disease in a cohort of coronary patients. J Clin Periodontol. 2012 Aug;39(8):699-706. doi: 10.1111/j.1600-051X.2012.01909.x. Epub 2012 Jun 12.
Other Identifiers
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F/34/08
Identifier Type: -
Identifier Source: org_study_id
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