Periodontitis and Atherosclerotic-related Arterial Stenosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-04-30

Study Completion Date

2022-04-30

Brief Summary

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This study aimed to evaluate the association between periodontitis and atherosclerosis of the cerebral vasculature in the Chinese population.

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Detailed Description

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Periodontitis has been demonstrated as a risk factor for ischaemic stroke in several clinical studies. Atherosclerosis of the cerebral vasculatureis an important pathological process causing ischaemic stroke. The investigator's study aims to investigate the relationship between tooth loss(used as a surrogate of periodontal disease) and atherosclerotic-related arterial stenosis in the Chinese population. An estimated 1,000 participants that underwent cerebral angiography at Guangdong Provincial Hospital of Chinese Medicine between Apirl 2020 and January 2022 will be recruited in this trial. Arterial stenosis features of each participants will be collected based on the results of digital subtraction angiography (DSA). The missing teeth counts of each participant will be collected and some of them will recieved comprehensive periodontal examination. Besides, blood samples will be collected in order to investigate the serum inflammatory markers(CRP,WBC,albumin,IL-6,IL-10). The relationship between tooth loss and atherosclerotic-related arterial stenosis will be analysed by regression models adjusted for conventional risk factors (sex,age, obesity,smoking,Alcohol drinking,diabetes,hypertension,hyperuricaemia,hyperhomocysteinaemia)

Conditions

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Atherosclerosis of Artery

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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0-9 missing teeth

participants with 0-9 missing teeth

No interventions assigned to this group

10-19 missing teeth

participants with 10-19 missing teeth

No interventions assigned to this group

23-31 missing teeth

participants with 23-31 missing teeth

No interventions assigned to this group

Edentulous

participants with no teeth

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. subjects who underwent cerebral angiography at Guangdong Provincial Hospital of Chinese Medicine from April 2020 to December 2021
2. subjects who voluntarily participated in this study and provided informed consent.

Exclusion Criteria

1. intracranial and extracranial artery stenosis caused by vascular inflammation, systemic connective tissue disease, and muscle fibre structure hypoplasia
2. inability to cooperate with the investigation
3. intracranial aneurysm and cerebral arteriovenous malformation confirmed by cerebral angiography
4. receipt of periodontal treatment in the previous 24 months.

Minimum Eligible Age

18 Years

Maximum Eligible Age

98 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No