Vitamin D and Periodontitis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-06-01

Study Completion Date

2016-04-21

Brief Summary

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Vitamin D has become important for periodontal disease due to play a role in autoimmunity, bone mineral metabolism and inflammation. Our aim was to investigate the relation between serum 25-hydroxy vitamin D levels, clinical periodontal parameters and blood serum biomarkers. The subjects were evaluated in 2 groups as chronic periodontitis (n= 30) and periodontally healthy subjects (n= 30). Periodontal parameters and fasting venous blood samples were taken from the subjects to assess each patient's periodontal status and for biochemical analyses (25-hydroxy vitamin D (25-OH vit D), osteoprotegerin (OPG), receptor activator of nuclear kappa B ligand (RANKL), C-telopeptide (CTx), tumor necrosis factor-α (TNF-α)).

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Detailed Description

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Conditions

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Alveolar Bone Loss

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Periodontally healthy subjects

fasting venous blood samples

Intervention Type DIAGNOSTIC_TEST

Chronic periodontitis patients

fasting venous blood samples

Intervention Type DIAGNOSTIC_TEST

Interventions

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fasting venous blood samples

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* never-smokers
* no history of systemic disease
* no patients had been under periodontal therapy and medicine for at least 6 months before the study
* no pregnancy or lactation
* no alcohol or antioxidant vitamin consumption.