Taurine in Periodontitis and Aging

NCT ID: NCT06635369

Last Updated: 2024-10-10

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 66 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-12-21
• Study Completion Date: 2024-06-01

Brief Summary

Aging leads to a decline in physiological functions and increases the risk of chronic diseases. Periodontitis is a chronic inflammatory disease that causes progressive destruction of the tissues supporting the teeth. Taurine, an amino acid with anti-inflammatory and antioxidant effects, might impact both periodontitis and aging. This study investigated taurine, SIRT1, and TNF-α levels in saliva and blood of 66 healthy people in different age groups, with or without periodontal disease. The findings showed that young people with healthy periodontal status had higher levels of taurine and SIRT1 compared to others. TNF-α, a marker of inflammation, was linked to the severity of periodontitis and may help identifying it in younger individuals. Overall, higher TNF-α levels are associated with periodontal inflammation, while taurine levels decrease with age-related inflammation.

Conditions

Peridontal Disease; Aging

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: NONE

Study Groups

Young (25-44 years) with a healthy periodontium

Group Type: EXPERIMENTAL

Periodontal Indices

Intervention Type: DIAGNOSTIC_TEST

Saliva, serum and periodontal indexes were obtained from patients

young (25-44 years) with Periodontitis

Group Type: EXPERIMENTAL

Periodontal Indices

Intervention Type: DIAGNOSTIC_TEST

Saliva, serum and periodontal indexes were obtained from patients

Old (≥65 years) with a healthy periodontium

Group Type: EXPERIMENTAL

Periodontal Indices

Intervention Type: DIAGNOSTIC_TEST

Saliva, serum and periodontal indexes were obtained from patients

Old (≥65 years) with Periodontitis

Group Type: EXPERIMENTAL

Periodontal Indices

Intervention Type: DIAGNOSTIC_TEST

Saliva, serum and periodontal indexes were obtained from patients

Interventions

Periodontal Indices

Saliva, serum and periodontal indexes were obtained from patients

Intervention Type: DIAGNOSTIC_TEST

Other Intervention Names

Salivary Flow Rate; TNF-α Levels; SIRT1 Levels; Taurine Levels

Eligibility Criteria

Exclusion Criteria

• ages 18-25 or 45-64
• use of antibiotics, anti-inflammatory drugs, immunosuppressants, beta-blockers, calcium channel blockers, or anticoagulants within the last 6 months
• presence of diabetes, rheumatoid arthritis, or other systemic conditions such as cardiovascular, renal, hepatic, and neurodegenerative disorders
• pregnancy or lactation
• alcoholism
• smoking
• nonsurgical periodontal treatment in the past 6 months or surgical treatment in the past 12 months
• having less than 20 natural teeth, excluding third molars
• use of orthodontic appliances

• Minimum Eligible Age: 26 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Istanbul Medipol University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Hadi Sayedyousef

Phd candidate

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Istanbul Medipol University

Istanbul, Unkapani, Turkey (Türkiye)

Countries

Turkey (Türkiye)

Other Identifiers

1078

Identifier Type: -

Identifier Source: org_study_id