The Effect Of Glycemic Control On Malondialdehyde, Glutathione Peroxidase, Glutathione And Paraoxonase
NCT ID: NCT01467674
Last Updated: 2011-11-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
84 participants
OBSERVATIONAL
2008-01-31
2009-05-31
Brief Summary
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Detailed Description
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Several researches revealed that DM, with many determinants such as level of glycemic control, stands as a strong risk factor for periodontal diseases. On the other side, periodontal diseases induce an elevated chronic inflammatory state and exacerbated insulin resistance.
In the present study, the investigators examined the effect of glycemic control level on clinical periodontal status, levels of MDA, GSH-Px, GSH and PON activity in gingival crevicular fluid and blood samples of CP patients with T2DM.
Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Healthy
No interventions assigned to this group
Chronic Periodontitis
No interventions assigned to this group
Better Controlled T2DM
No interventions assigned to this group
Poor Controlled T2DM
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* diagnosis of CP was based on the clinical and radiographic criteria proposed by the 1999 World Workshop for Classification of Periodontal Diseases and Conditions
Exclusion Criteria
* lactation
* current smoking or smoking within the past 2 years, periodontal therapy in the previous 6 months
* antibiotic and/or antimicrobial therapies in the previous 3 months
* existence of serious diabetic complications or any pathology such as haemoglobinopathy which would affect haemoglobin profile
* diagnosis of another major medical pathology, middle or upper-level obesity according to WHO classification
* current anti-hyperlipidemic therapy
* non-T2DM patients with abnormal values of glucose and lipid metabolism parameters, major medical pathology and family history of DM
ALL
Yes
Sponsors
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Suleyman Demirel University
OTHER
Responsible Party
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Dr. Yener ÖZAT
Assistant Professor
Principal Investigators
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F. Yeşim Kırzıoğlu, 1
Role: STUDY_DIRECTOR
Professor, Periodontology Dept
Mustafa Nazıroğlu, 1
Role: STUDY_DIRECTOR
Professor, Biophysics Dept
M. Numan Tamer, 1
Role: STUDY_DIRECTOR
Professor, Internal Diseases Dept.
Locations
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Suleyman Demirel University
Isparta, , Turkey (Türkiye)
Countries
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Other Identifiers
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1721-D-08
Identifier Type: -
Identifier Source: org_study_id