Study Results
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Basic Information
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COMPLETED
PHASE1
24 participants
INTERVENTIONAL
2017-08-30
2018-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
TRIPLE
Study Groups
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Scaling and root planning (SRP)
Under local anesthesia, full-mouth SRP was performed within 24 h in a single or two sessions using ultrasonic and hand instruments (Gracey, Hu-Friedy, Chicago, IL, USA) by a single investigator (DA). Immediately after the SRP, HA gel (Gengigel, Hyaluronic acid, gingival gel, Ricefarma S.R.L, Italy) or mouthrinse was performed according to the groups' procedure. In Group 1, the periodontal sulcus was irrigated with saline solution after SRP.
Scaling and root planning
Under local anesthesia, full-mouth SRP will be performed by a single investigator. Immediately after the SRP, HA gel or mouthrinse will perform according to the groups' procedure. In Group 1, the periodontal sulcus will be irrigated with saline solution after SRP.
Hyaluronic acid gel (HA) and SRP
Group 2, after SRP was performed and irrigated with saline the area was dried with a soft air and, then, a gel containing HA was applied intrasulcular.
Scaling and root planning
Under local anesthesia, full-mouth SRP will be performed by a single investigator. Immediately after the SRP, HA gel or mouthrinse will perform according to the groups' procedure. In Group 1, the periodontal sulcus will be irrigated with saline solution after SRP.
Hyaluronic acid gel (HA) and SRP
In Group 2, after SRP will be performed and irrigated with saline the area was dried with a soft air and, then, a gel containing HA will be applied intrasulcular.
HA mouthrinse and SRP
In Group 3, HA hydrogel mouthrinse (Gengigel, Hyaluronic acid, Hydrogel moutrinse for gums, Ricefarma S.R.L, Italy) were used as an irrigator after SRP.
Scaling and root planning
Under local anesthesia, full-mouth SRP will be performed by a single investigator. Immediately after the SRP, HA gel or mouthrinse will perform according to the groups' procedure. In Group 1, the periodontal sulcus will be irrigated with saline solution after SRP.
HA mouthrinse and SRP
In Group 3, HA hydrogel mouthrinse will be used as an irrigator after SRP.
HA mouthrinse+gel and SRP
In Group 4, after SRP was performed, the sulcus was irrigated with HA hydrogel mouthrinse and, then, intrasulculary HA gingival gel was applied.
Scaling and root planning
Under local anesthesia, full-mouth SRP will be performed by a single investigator. Immediately after the SRP, HA gel or mouthrinse will perform according to the groups' procedure. In Group 1, the periodontal sulcus will be irrigated with saline solution after SRP.
HA mouthrinse+gel and SRP
In Group 4, after SRP will be performed, the sulcus was irrigated with HA hydrogel mouthrinse and, then, intrasulculary HA gingival gel will be applied.
Interventions
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Scaling and root planning
Under local anesthesia, full-mouth SRP will be performed by a single investigator. Immediately after the SRP, HA gel or mouthrinse will perform according to the groups' procedure. In Group 1, the periodontal sulcus will be irrigated with saline solution after SRP.
Hyaluronic acid gel (HA) and SRP
In Group 2, after SRP will be performed and irrigated with saline the area was dried with a soft air and, then, a gel containing HA will be applied intrasulcular.
HA mouthrinse and SRP
In Group 3, HA hydrogel mouthrinse will be used as an irrigator after SRP.
HA mouthrinse+gel and SRP
In Group 4, after SRP will be performed, the sulcus was irrigated with HA hydrogel mouthrinse and, then, intrasulculary HA gingival gel will be applied.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* moderate-to-severe periodontitis
* at least five sites with ≥5mm probing depth (PD)
* at least ≥20 teeth
* Stage II-III periodontitis according to the 2017 World Workshop
* Age between18-55
Exclusion Criteria
* prior surgical or non-surgical periodontal treatment within the past six months
* smoking
* pregnancy
* lactation
* age ≤18 years or ≥55 years
* hypertension
* known chronic systemic diseases (i.e., diabetes mellitus, rheumatoid arthritis), - - known hypersensitivity to one of the ingredients of the HA preparation.
18 Years
55 Years
ALL
No
Sponsors
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Yuzuncu Yıl University
OTHER
Responsible Party
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Hacer Sahin Aydinyurt
Assist Prof
Principal Investigators
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Hacer Sahin Aydinyurt, Assist Prof
Role: STUDY_DIRECTOR
Yuzuncu Yıl University
Locations
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Van Yuzuncu Yil University Faculty of Dentistry
Van, , Turkey (Türkiye)
Countries
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References
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Aydinyurt HS, Akbal D, Altindal D, Bozoglan A, Ertugrul AS, Demir H. Evaluation of biochemical and clinical effects of hyaluronic acid on non-surgical periodontal treatment: a randomized controlled trial. Ir J Med Sci. 2020 Nov;189(4):1485-1494. doi: 10.1007/s11845-020-02230-6. Epub 2020 May 21.
Other Identifiers
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19.07.2017/09
Identifier Type: -
Identifier Source: org_study_id
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