Effects of the Adjunctive Use of Hyaluronic Acid-based Gel in the Surgical Periodontal Treatment of Periodontitis
NCT ID: NCT06842511
Last Updated: 2025-02-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE1/PHASE2
18 participants
INTERVENTIONAL
2023-04-04
2024-05-30
Brief Summary
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Detailed Description
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This split-mouth study included 18 patients (mean age 43.44±8.12 years) diagnosed with Stage III Grade B or C periodontitis. Quadrants were randomly assigned to two groups: Group 1 (control: open flap debridement \[OFD\], n=18) and Group 2 (test: OFD + 0.8% HA gel, n=18). Baseline (T0) assessments included plaque index (PI), gingival index (GI), bleeding on probing index (BPI), probing pocket depth (PPD), clinical attachment level (CAL), and GCF collection. Following non-surgical treatment, patients underwent OFD; HA gel was applied to defect sites in the test group and saline in the control. Clinical parameters and GCF sampling were repeated pre-surgery (TS-1), and at 1 month (TS-2) and 6 months (TS-3) post-surgery.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Control group
only open flap debridement
open flap debridement
periodontal surgery technique
Test group
open flap debridement + adjunctive use of 0.8% hyaluronic acid-based gel
open flap debridement and Hyaluronic Acid-Based Gel application
Hyaluronic Acid-based gel as an adjunctive chemotherapeutic agent
open flap debridement
periodontal surgery technique
Interventions
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open flap debridement and Hyaluronic Acid-Based Gel application
Hyaluronic Acid-based gel as an adjunctive chemotherapeutic agent
open flap debridement
periodontal surgery technique
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* over 18 years old
* signed the informed consent
Exclusion Criteria
* systemic problems that would contraindicate for periodontal surgery,
* prosthetic restorations in the test or control teeth,
* taking medications that affect wound healing (corticosteroids, anticancer agents, etc),
* using nonsteroidal anti-inflammatory drugs, using any antibiotics and anti-inflammatory drugs in the last 6 months,
* alcohol abuse and smoking use
25 Years
55 Years
ALL
No
Sponsors
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Ordu University
OTHER
Responsible Party
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Prof.Dr. Figen ÖNGÖZ DEDE
Clinical Professor
Principal Investigators
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Ordu University
Role: PRINCIPAL_INVESTIGATOR
Ordu University
Locations
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Ordu University
Ordu, Altınordu, Turkey (Türkiye)
Countries
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Other Identifiers
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77158231
Identifier Type: -
Identifier Source: org_study_id
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