The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodontitis

NCT ID: NCT05043935

Last Updated: 2024-04-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-11-22

Study Completion Date

2024-10-31

Brief Summary

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Antimicrobial photodynamic therapy (aPDT) is associated with photosensitizing agents which promote the generation of free radicals and singlet oxygen, which are cytotoxic to certain bacteria. Leukocyte and platelet-rich fibrin (L-PRF) has been used extensively in the treatment of intrabony defects and achieved excellent results. It acts as an immune regulation node with inflammation control abilities, including a slow continuous release of growth factors which stimulates periodontal regeneration. The aim of this study is to evaluate the adjunctive effects of aPDT with and without L-PRF in aggressive periodontitis patients.

Detailed Description

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Conditions

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L-PRF Photodynamic Therapy Aggressive Periodontitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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L-PRF with antimicrobial photodynamic therapy

Application of L-PRF with antimicrobial photodynamic therapy in the defect

Group Type EXPERIMENTAL

L-PRF with antimicrobial photodynamic therapy

Intervention Type PROCEDURE

Application of L-PRF with antimicrobial photodynamic therapy in the defect

antimicrobial photodynamic therapy

Application antimicrobial photodynamic therapy in the defect

Group Type ACTIVE_COMPARATOR

antimicrobial photodynamic therapy without L-PRF

Intervention Type PROCEDURE

application of antimicrobial photodynamic therapy without L-PRF in the defect

Interventions

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L-PRF with antimicrobial photodynamic therapy

Application of L-PRF with antimicrobial photodynamic therapy in the defect

Intervention Type PROCEDURE

antimicrobial photodynamic therapy without L-PRF

application of antimicrobial photodynamic therapy without L-PRF in the defect

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* systemically healthy
* non- smoker,
* not received any periodontal treatment within the last 6 months,
* no antibiotics, anti- inflammatory drugs or any other medication taken within the last 6 months

Exclusion Criteria

* any systemic disease that might influence the prognosis of periodontal disease and outcome of the treatment,
* any medical condition that required antibiotic prophylaxis before the treatment,
* smoking,
* pregnancy and lactation,
* ingestion of antibiotics, anti-inflammatory drugs or any other medication during the study period,
* any physical limitations or restrictions that might preclude normal oral hygiene procedures.
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Kafrelsheikh University

OTHER

Sponsor Role lead

Responsible Party

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Dalia Rasheed Issa

principle investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dalia R Issa, PhD

Role: PRINCIPAL_INVESTIGATOR

Kafrelsheikh University

Locations

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Faculty of Dentistry, Kafrelsheikh University

Kafr ash Shaykh, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Dalia R Issa, PhD

Role: CONTACT

01007753636 ext. 002

Facility Contacts

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Dalia R Issa, PhD

Role: primary

01007753636 ext. 002

Other Identifiers

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waiting

Identifier Type: -

Identifier Source: org_study_id

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