Photodynamic Therapy and Periodontal Therapy. A Clinical, Microbiological and Immunoenzymatic Analysis
NCT ID: NCT01670305
Last Updated: 2013-09-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
75 participants
INTERVENTIONAL
2011-02-28
2013-03-31
Brief Summary
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Detailed Description
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1\) the effect of a single PDT as monotherapy residual pockets in single rooted teeth and 2) the effect of PDT in association with SRP in class II furcation lesions.
A blind randomized controlled clinical trial was conducted in subjects presenting at least three residual pockets in single root teeth and subjects with at least one molar presenting class II furcation involvement.
To evaluate the effect of a single PDT as monotherapy in residual pockets, the selected sites were assigned to receive one of following therapies: PDT alone, photosensitizer alone or SRP alone.
To evaluate the effect of PDT in association with SRP in class II furcation lesions, the selected sites were assigned to receive PDT+SRP or SRP alone. Microbiological, immunoenzymatic analyses and clinical parameters: probing pocket depth (PPD), position of the gingival margin (PGM), relative clinical attachment level (RCAL), full mouth plaque (FMPS) and bleeding score (FMBS), will be assessed at baseline,3 and 6 months post-therapies.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Residual pocket - PDT
Photosensitizer plus diiodo laser
Residual pockets will be treated by laser + photosensitizer
Experimental group: Residual pockets will be treated by laser + photosensitizer
Residual pocket - Photosensitizer
Photosensitizer alone
Residual pockets will be treated only photosensitizer
Placebo Comparator: Residual pockets will be treated only photosensitizer
Residual pocket - SRP
scaling and root planing alone
Residual pockets will be treated scaling and root planing
Active Comparator: Residual pockets will be treated scaling and root planing
Furcation - PDT+SRP
Photosensitizer plus diiodo laser associated with scaling and root planing
laser + photosensitizer associated with scaling and root planing
Experimental group: furcation defects will be treated by laser + photosensitizer associated with scaling and root planing
Furcation - SRP
Photosensitizer associated with scaling and root planing
furcation defects will be treated by scaling and root planing
Active Comparator: furcation defects will be treated by scaling and root planing
Interventions
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Residual pockets will be treated by laser + photosensitizer
Experimental group: Residual pockets will be treated by laser + photosensitizer
Residual pockets will be treated only photosensitizer
Placebo Comparator: Residual pockets will be treated only photosensitizer
Residual pockets will be treated scaling and root planing
Active Comparator: Residual pockets will be treated scaling and root planing
laser + photosensitizer associated with scaling and root planing
Experimental group: furcation defects will be treated by laser + photosensitizer associated with scaling and root planing
furcation defects will be treated by scaling and root planing
Active Comparator: furcation defects will be treated by scaling and root planing
Eligibility Criteria
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Inclusion Criteria
* at least three contralateral single rooted teeth with residual PPD \> 5mm with bleeding on probing (BoP) in supportive periodontal therapy or with at least one molar presenting class II furcation defect.
Exclusion Criteria
* lactation
* current smoking and smoking within the past 10 years
* antibiotic therapies in the previous 6 months
* use of mouth rinses containing antimicrobials in the preceding 2 months
* systemic conditions that could affect the progression of periodontitis
* orthodontic appliances
* use of long-term administration of anti-inflammatory and immunosuppressive medications
30 Years
80 Years
ALL
Yes
Sponsors
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Paulista University
OTHER
Responsible Party
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Marcio Zaffalon Casati
Professor
Locations
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School of dentistry - Paulista University UNIP
São Paulo, São Paulo, Brazil
Countries
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Related Links
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Related Info
Other Identifiers
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0272.0.251.000-10
Identifier Type: -
Identifier Source: org_study_id