Evaluation of L-PRF as an Antibiotic Slow-release Biological Device in the Treatment of Moderate Periodontitis
NCT ID: NCT06153706
Last Updated: 2023-12-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE2/PHASE3
24 participants
INTERVENTIONAL
2022-06-01
2023-10-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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L-PFR loaded with medical grade metronidazole
Subgingival application of L-PRF loaded with metronidazole
After phase I therapy, L-PRF loaded medical grade metronidazole was applied sub gingivally into the pockets using blunt gauge needle and Perio-pack was placed (two applications with one week apart were applied subgingivally.
L-PFR
Subgingival application of L-PRF
The L-PRF alone was applied subgingivally into the pockets and Perio-pack was placed (two applications with one week apart.
Interventions
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Subgingival application of L-PRF loaded with metronidazole
After phase I therapy, L-PRF loaded medical grade metronidazole was applied sub gingivally into the pockets using blunt gauge needle and Perio-pack was placed (two applications with one week apart were applied subgingivally.
Subgingival application of L-PRF
The L-PRF alone was applied subgingivally into the pockets and Perio-pack was placed (two applications with one week apart.
Eligibility Criteria
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Inclusion Criteria
* Patients showing good oral hygiene.
* No history of periodontal therapy (surgical and non-surgical) for the past 6 months.
Exclusion Criteria
* Patients who had any previous adverse reactions to the products (or similar products) used in this study.
* Patients who have any autoimmune diseases.
* Patients who have any known disease that interfere with periodontal procedure.
* Smokers.
* Pregnancy and lactating women.
* Use of antibiotics during the last 6 months.
25 Years
50 Years
ALL
No
Sponsors
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Yasmeen Khaled
OTHER
Responsible Party
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Yasmeen Khaled
Periodontology Masters degree candidate
Principal Investigators
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Yasmeen K Omar, BDS
Role: PRINCIPAL_INVESTIGATOR
Alexandria University
Mohy A El Rashidy, PhD
Role: STUDY_DIRECTOR
Alexandria University
Ghada Bassiouny, PhD
Role: STUDY_CHAIR
Alexandria University
Aliaa G Aboulela, PhD
Role: STUDY_CHAIR
University of Alexandria
Locations
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Faculty of Dentistry, Alexandria University
Alexandria, , Egypt
Countries
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References
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Omar YK, Rashidy MAE, Ahmed GB, Aboulela AG. Evaluation of leukocyte-platelet rich fibrin as an antibiotic slow-release biological device in the treatment of moderate periodontitis: a randomized controlled clinical trial. BMC Oral Health. 2024 Dec 21;24(1):1530. doi: 10.1186/s12903-024-05254-x.
Other Identifiers
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#6/22
Identifier Type: -
Identifier Source: org_study_id