Gene Expression Profiles in Chronic Periodontitis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

46 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-02-28

Study Completion Date

2017-05-31

Brief Summary

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Current concepts of the causes of periodontitis implicate a bacterial infection as the primary cause of the disease. Several bacterial species residing in a biofilm on tooth surfaces are closely associated with periodontitis. Chronic periodontitis (CP) is initiated and sustained by bacterial plaque, but host defense mechanisms play an integral role in its pathogenesis.

Gene expression profiling is a powerful means of generating comprehensive genome-level data sets on diseases such as cancer, asthma, rheumatoid disorders and periodontitis, and provides significant insight information for these diseases. Gene expression profiling may provide an evidence for involving genes in the pathogenesis of CP and generate further information other than clinical signs and symptoms of CP.

The aim of this study was to identify gene-expression patterns of patients with chronic periodontitis by whole-transcriptome gene-expression analyses.

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Detailed Description

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Conditions

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Chronic Periodontitis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Patients with Chronic Periodontitis

All subjects were free of systemic diseases and to be included, individuals had to be older than 18 years of age.

Chronic periodontitis was diagnosed according to American Academy of Periodontology 1999 Consensus Report.

Genom-based whole-genome transcriptomic

Intervention Type GENETIC

Gene expression profiling is a powerful means of generating comprehensive genome-level data sets.

Control Patients

Control subjects had no radiographic evidence of bone loss or any sign of past and present periodontitis.

All subjects were free of systemic diseases and to be included, individuals had to be older than 18 years of age.

Genom-based whole-genome transcriptomic

Intervention Type GENETIC

Gene expression profiling is a powerful means of generating comprehensive genome-level data sets.

Interventions

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Genom-based whole-genome transcriptomic

Gene expression profiling is a powerful means of generating comprehensive genome-level data sets.

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

1. CP patients had at least 20 teeth exhibiting \>30% of measured sites with \>5mm clinical attachment loss.
2. Had bleeding on probing (BOP) at \>50% of the proximal sites.

Exclusion Criteria

1. Had any known systemic diseases that can influence the periodontal status, oral diseases other than chronic periodontitis and ongoing orthodontic therapy.
2. History of hepatitis, HIV infection, or diabetes; requirement for antibiotic prophylaxis, pregnancy or lactation; and long-term use of anti-inflammatory drugs.
3. Should be free of systemic diseases
4. Individuals had to be older than 18 years of age.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes