Study of Postoperative Cognitive Decline in Aged Patients

NCT ID: NCT03765840

Last Updated: 2018-12-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-05-01

Study Completion Date

2021-05-31

Brief Summary

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postoperative cognitive decline is a common and deleterious complication in aged patients.The link between inflammation and postoperative cognitive decline has also been reported.However,the link between SOD1,SOD2,Osteopontin, Kallikrein-6,and Contactin-1 and postoperative cognitive decline is unknown. In this project ,investigators examine the relationship between 5 cytokines measured at there timepoints (preoperative \[PREOP\], postoperative day 1 \[POD1\] , and postoperative day 3\[POD2\]) and postoperative cognitive decline among older adults undergoing orthopedic surgery.

Detailed Description

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Conditions

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Cognitive Decline

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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POCD group

patients occur cognitive decline after surgery according to scores in this group.

No interventions assigned to this group

NO POCD group

patients do not occur cognitive decline after surgery according to scores in this group.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* patients who are more than 65 years old
* patients who undergo orthopedic surgery(trauma ,especially fracture of lower limb)
* patients with ASA physical status I-III
* patients who have a consent

Exclusion Criteria

* patients who are more than 85 years old
* patients with ASA physical status \>III
* patients who have neurological disorders, stroke or other affective central nervous system diseases
* patients who have a history of serious psychiatric illness
* patients with long-term use of psychoactive substances
* patients who undergo multiple trauma and the presence of head injury
Minimum Eligible Age

65 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Jia-feng Wang

OTHER

Sponsor Role lead

Responsible Party

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Jia-feng Wang

M.D

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Deartment of anesthesiology,changhai hospital

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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wenbin lu

Role: CONTACT

86+21-31161841

Facility Contacts

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Xi-Ya Yu, M.D.

Role: primary

+86-21-31161841

Other Identifiers

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POCD-aged

Identifier Type: -

Identifier Source: org_study_id

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