Biomarkers and Risk Factors for Perioperative Neurocognitive Dysfunction in Elderly Patients

NCT ID: NCT06044207

Last Updated: 2023-09-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-06-01

Study Completion Date

2026-01-01

Brief Summary

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Basic information and biological samples of patients were collected preoperatively and intraoperatively, and patients were divided into case and control groups by cognitive function assessment postoperatively, and risk factors and biomarkers of perioperative cognitive dysfunction were derived by analyzing and statistically processing basic information and biological samples.

Detailed Description

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Conditions

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Perioperative Neurocognitive Dysfunction

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with perioperative neurocognitive dysfunction

Pittsburgh sleep quality index

Intervention Type DIAGNOSTIC_TEST

The scale is suitable for evaluating sleep quality in patients with sleep disorders and psychiatric disorders, as well as for assessing sleep quality in the general population.

Self-rating depression scale

Intervention Type DIAGNOSTIC_TEST

The scale is easy to use, can fairly intuitively reflect whether the patient has depression and the degree of depression, has been widely used in outpatient gross screening, mood state assessment.

Montreal Cognitive Assessment

Intervention Type DIAGNOSTIC_TEST

The scale is a tool used for rapid screening of mild cognitive dysfunction to identify patients with preoperative cognitive dysfunction

Patients without perioperative neurocognitive dysfunction

Pittsburgh sleep quality index

Intervention Type DIAGNOSTIC_TEST

The scale is suitable for evaluating sleep quality in patients with sleep disorders and psychiatric disorders, as well as for assessing sleep quality in the general population.

Self-rating depression scale

Intervention Type DIAGNOSTIC_TEST

The scale is easy to use, can fairly intuitively reflect whether the patient has depression and the degree of depression, has been widely used in outpatient gross screening, mood state assessment.

Montreal Cognitive Assessment

Intervention Type DIAGNOSTIC_TEST

The scale is a tool used for rapid screening of mild cognitive dysfunction to identify patients with preoperative cognitive dysfunction

Interventions

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Pittsburgh sleep quality index

The scale is suitable for evaluating sleep quality in patients with sleep disorders and psychiatric disorders, as well as for assessing sleep quality in the general population.

Intervention Type DIAGNOSTIC_TEST

Self-rating depression scale

The scale is easy to use, can fairly intuitively reflect whether the patient has depression and the degree of depression, has been widely used in outpatient gross screening, mood state assessment.

Intervention Type DIAGNOSTIC_TEST

Montreal Cognitive Assessment

The scale is a tool used for rapid screening of mild cognitive dysfunction to identify patients with preoperative cognitive dysfunction

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Age more than or equal to 65 years old
* ASA classification Ⅰ\~Ⅲ grade

Exclusion Criteria

* History of previous Craniocerebral surgery or Craniocerebral trauma
* Inability to successfully complete preoperative psychological function tests
* Those who are severely deaf, speech impaired and otherwise unable to communicate.
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Jinan Central Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Jinan Central Hospital

Jinan, Shandong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Wenying Chi, Master

Role: CONTACT

18654557772

Facility Contacts

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Wenying Chi, Master

Role: primary

18654557772

Other Identifiers

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2023-076-01

Identifier Type: -

Identifier Source: org_study_id

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