Preoperative Pain and POCD in Elderly Patients

NCT ID: NCT03393676

Last Updated: 2020-03-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-10

Study Completion Date

2020-03-31

Brief Summary

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The purpose of this study is to investigate whether preoperative pain is the risk factor of POCD in elder patients.

Detailed Description

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Postoperative cognitive dysfunction (POCD) occurs mainly in aged patients. The mechanism of POCD is not clear yet and no effective therapy method. In the present study, we conducted a single-center observational prospective cohort trial in elder patients who undergoing hip joint replacement surgery with general anesthesia to test our hypothesis that preoperative chronic pain is one of the risk factors of POCD after major joint replacement surgery.

Conditions

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Postoperative Cognitive Dysfunction

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1. Elder than 65 years old
2. Speak Chinese Mandarin
3. Those who will undergo major low limb surgery like hemiarthroplasty or total hip arthroplasty with general anesthesia.
4. Signed the inform consent
5. American Society of Anesthesiologists classification I to II

Exclusion Criteria

1. Existing cerebral disease, or have a history of neurological and psychiatric disease including Alzheimer Disease, stroke, epilepsy and psychosis
2. Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
3. Severe hearing or visual impairment
4. Unwillingness to comply with the protocol or procedures
5. Cannot communicate with Chinese Mandarin
6. Serious pulmonary, heart , liver or renal insufficiency patients
7. Had anesthesia or surgery within the past 30 days
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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RenJi Hospital

OTHER

Sponsor Role lead

Responsible Party

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Xiaorong Huai

Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Weifeng Yu, MD

Role: STUDY_CHAIR

Anesthesiology Department Renji Hospital, Shanghai

Locations

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Reni Hospital, Shanghai Jiao Tong University, School of Medicine

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Shanghai Ren ji Hospital

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Xiaorong Huai, MS

Role: CONTACT

13818003683

Diansan Su, MD

Role: CONTACT

18616514088

Facility Contacts

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Xiaorong Huai, MS

Role: primary

13818003683

Diansan Su, MD

Role: backup

18616514088

Xiaorong Huai, MS

Role: primary

+8613818003683

Diansan Su, MD

Role: backup

+8618616514088

References

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Huai X, Jiao Y, Gu X, Zhu H, Chen L, Fan Y, Yu W, Su D, Xie H. Preoperative Chronic Pain as a Risk Factor for Early Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Hip Joint Replacement Surgery: A Prospective Observational Cohort Study. Front Neurosci. 2021 Dec 17;15:747362. doi: 10.3389/fnins.2021.747362. eCollection 2021.

Reference Type DERIVED
PMID: 34975369 (View on PubMed)

Other Identifiers

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PPOCD20161201

Identifier Type: -

Identifier Source: org_study_id

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