Screening of Susceptibility Genes in Postoperative Cognitive Dysfunction(POCD)

NCT ID: NCT02084030

Last Updated: 2014-08-15

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 120 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2013-03-31
• Study Completion Date: 2014-09-30

Brief Summary

The aim of this study is to perform a whole-genome linkage analysis for identification of the susceptibility loci for POCD

Detailed Description

BACKGROUND: Postoperative cognitive dysfunction is probably the most frequent type of postoperative cognitive impairment. As it mainly affect the elderly population, POCD is receiving increasing attention. However, the pathophysiology of POCD remains incompletely understood. No study had elucidate why somebody are apt to suffer from POCD, but others not. In current study, we try to use GWAS technology to find out whether there is a correlation between POCD and gene specificity.

DESIGNING: 120 patients will be screened who are schedule to receive selective on-pump cardiac surgery， 5 ml blood of the patient will be collected before anesthesia induction. Investigetors will measure the cognitive function of the patients one day before surgery and 7 d after surgery and identify whether the patient suffer from POCD used in MMSE test. Randomly select 36 patients who suffer from POCD and 36 patients without POCD(control), GWAS technology will be used to screen the susceptibility gene between these two groups.

EXPECTED RESULTS ：Find out some susceptibility genes correlate to POCD.

CONCLUSIONS: The patients who are apt to suffer from POCD have some special susceptibility genes differ from normal people.

Conditions

Cardiac Surgery Patients

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

Experimental: Patient with POCD

Patients who suffer from POCD after surgery. The mini-mental state examination scale decline more than 1 SD of baseline after surgery.

No interventions assigned to this group

Sham Comparator: patient without POCD

Patients who don't suffer from POCD after surgery. There is no obvious difference between pre-operation and post-operation in mini-mental state examination scale

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

1. Age from 60 to 75 years old;

2. Schedule for on-pump cardiac surgery;

3. undergoing full intravenous anesthesia;

4. without hepatic, renal, pulmonary disease or full intravenous anesthesia surgery history;

5. Gave the informed consent.

Exclusion Criteria

1. Emergency surgery;

2. A history of cerebrovascular disease;

3. The history of mental disease;

4. Long term use of sedative and antidepressant drugs;

5. Alcoholism;

6. serious vision, hearing impairment and inapprehensive language;

7. chromosomal abnormalities;

8. blood disease;

9. refused to sign the informed consent.

• Minimum Eligible Age: 60 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Xijing Hospital

OTHER

Sponsor Role: lead

Responsible Party

HailongDong

MD, PhD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Hailong Dong, MD,PhD

Role: PRINCIPAL_INVESTIGATOR

Xijing Hospital

Locations

Xijing Hospital

Xi'an, Shaanxi, China

Site Status: RECRUITING

Countries

China

Central Contacts

Hailong DONG, MD, PhD

Role: CONTACT

hldong6@hotmail.com

86-2984775337

Facility Contacts

Hailong Dong, MD,PhD

Role: primary

hldong6@hotmail.com

86-2984775337

Other Identifiers

DONG2014POCD

Identifier Type: -

Identifier Source: org_study_id