Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
1250 participants
OBSERVATIONAL
2020-05-05
2023-04-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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with postoperative cognitive dysfunction
EEG(Electroencephalogram) change
patients are found to have characteristic EEG change
without postoperative dysfunction
EEG(Electroencephalogram) change
patients are found to have characteristic EEG change
Interventions
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EEG(Electroencephalogram) change
patients are found to have characteristic EEG change
Eligibility Criteria
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Inclusion Criteria
2. non-cardiac surgery under general anesthesia;
3. American Society of Anesthesiology(ASA) classification I- II
4. Patients aged 18-40 years old are set as background
Exclusion Criteria
2. preoperative minimal mental status examination(MMSE) score\<24;
3. ASA status III or higher
3\) those who have received less than 5 years of education since entering primary school; 4) history of sedatives or antidepressants use; 5) existed or anticipated alcohol or drug abuse(over 40°c and over 100ml per day for the past 3 months); 6) history of surgery within the previous year; 7) those with severe visual or hearing impairment; 8) those participated in other clinical studies within last 3 months;
65 Years
100 Years
ALL
No
Sponsors
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Air Force Military Medical University, China
OTHER
Responsible Party
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Zhihong LU
professor
Locations
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Suzhou First People's Hospital
Suzhou, Jiangsu, China
The First Affiliated Hospital Nanchang University
Nanchang, Jiangxi, China
General Hospital of Northern Theater Command
Shenyang, Liaoning, China
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China
Qinhai Provincial People's Hospital
Xining, Qinghai, China
The Second Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China
First Hospital of Shanxi Medical University
Taiyuan, Shanxi, China
Second Hospital of Shanxi Medical University
Taiyuan, Shanxi, China
Shanxi Bethune Hospital
Taiyuan, Shanxi, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
China-Japan Friendship Hospital
Beijing, , China
Xinqiao Hospital of Army Medical University
Chongqing, , China
People's Hospital of Jiangsu
Nanjing, , China
Weinan Central Hospital
Weinan, , China
Zhongnan Hospital of Wuhan University
Wuhan, , China
People's Hospital of Zhanjiang
Zhanjiang, , China
People's Hospital of Zhengzhou University
Zhengzhou, , China
Traditional Chinese Medicine Hospital of Henan
Zhengzhou, , China
Countries
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Central Contacts
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Facility Contacts
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Fuhai Ji
Role: primary
Shibiao Chen
Role: primary
Yugang Diao
Role: primary
Xinli Ni
Role: primary
Yun Wang
Role: primary
Jianrui Lv
Role: primary
Shouyuan Tian
Role: primary
Linzhong Zhang
Role: primary
Chongfang Han
Role: primary
Jing Zhao
Role: primary
Hong Li
Role: primary
Cunming Liu
Role: primary
Jianzhong Ma
Role: primary
Mian Peng
Role: primary
Tao Tao
Role: primary
Jiaqiang Zhang
Role: primary
Xihua Lu
Role: primary
References
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Vutskits L, Xie Z. Lasting impact of general anaesthesia on the brain: mechanisms and relevance. Nat Rev Neurosci. 2016 Oct 18;17(11):705-717. doi: 10.1038/nrn.2016.128.
Monk TG, Weldon BC, Garvan CW, Dede DE, van der Aa MT, Heilman KM, Gravenstein JS. Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology. 2008 Jan;108(1):18-30. doi: 10.1097/01.anes.0000296071.19434.1e.
Abildstrom H, Rasmussen LS, Rentowl P, Hanning CD, Rasmussen H, Kristensen PA, Moller JT. Cognitive dysfunction 1-2 years after non-cardiac surgery in the elderly. ISPOCD group. International Study of Post-Operative Cognitive Dysfunction. Acta Anaesthesiol Scand. 2000 Nov;44(10):1246-51. doi: 10.1034/j.1399-6576.2000.441010.x.
Other Identifiers
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XJH-A-20190726
Identifier Type: -
Identifier Source: org_study_id
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