EEG Spectrogram, Brain Vulnerability and POD

NCT ID: NCT05368272

Last Updated: 2024-02-28

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 30 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-01-27
• Study Completion Date: 2023-12-06

Brief Summary

An assessment of difference in prespecified processed electroencephalography variables between cognitively intact older surgical patients who develop postoperative delirium compared to those who do not develop postoperative delirium

Detailed Description

Postoperative delirium in older people may be contributed to by intrinsic brain vulnerability such as pre-existing dementia. Some cognitively intact older people also experience postoperative delirium and in these patients some go on to develop later dementia. The investigators propose that postoperative delirium may be an unmasking of covert brain vulnerability by the dyshomeostasis of the anaesthesia/surgical intervention.

In people with dementia or mild cognitive impairment, electroencephalography (EEG) studies have shown slowing of brain wave activity, especially in the back of the brain.

Processed electroencephalography, using a limited number of channels, is routinely used during anaesthesia to aid assessment of anaesthetic depth of the patient.

In this study the investigators will assess the feasibility of acquiring EEG data from the front and back of the brain. The investigators will also explore the data for early signals of brain vulnerability

Conditions

Postoperative Delirium

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

Processed electroencephalography

Acquisition of raw EEG data from processed EEG monitor. Analysis of data acquired for prespecified bandwidth properties

Intervention Type: OTHER

Postoperative delirium assessment

Twice daily assessment for the incidence of postoperative delirium using validated tool (questionnaire)

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• ≥ 65 years old
• Elective, moderate/major, non-neuro, non-cardiac surgery
• Ability to give informed consent

Exclusion Criteria

• Preoperative cognitive impairment
• Current systemic infection
• Current use of medication that may modify EEG
• History of neurosurgery/significant head trauma
• Presence of neurological diseases including overt stroke, dementia, epilepsy, multiple sclerosis, Parkinson's disease, intracranial tumours and other significant neurologic disorders
• Current significant psychiatric conditions such as severe depression.
• Palliative surgery

• Minimum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Nottingham

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Iain Moppett, FRCA, MD

Role: PRINCIPAL_INVESTIGATOR

University of Nottingham

Locations

Queen's Medical Centre

Nottingham, , United Kingdom

Countries

United Kingdom

Other Identifiers

21074

Identifier Type: -

Identifier Source: org_study_id