Elderly Patients Undergoing Surgery During Perioperative Period

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-12-30

Study Completion Date

2030-12-30

Brief Summary

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The elderly patients have poorer overall conditions and have lower tolerance to trauma, anesthesia, and surgery. Therefore, the incidence of postoperative complications is relatively higher. In non-cardiac surgeries, approximately 20% of elderly patients experience postoperative complications, and the incidence of postoperative delirium (POD) is 23.8%. This may lead to prolonged hospital stays, increased hospital costs, and affect prognosis and even mortality. The investigators plan to conduct a prospective cohort study by systematically collecting biological samples and clinical information of elderly patients during the perioperative period to explore the possible risk factors and pathogenesis of postoperative delirium and postoperative complications in elderly surgical patients, and to construct a risk prediction model for postoperative complications.

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Detailed Description

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Conditions

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Postoperative Complications Elderly Postoperative Delirium (POD) Risk Prediction Model Pathogenesis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Surgical patients aged 65 years or older

For the surgical group patients, questionnaires and scales measuring cognitive function, sleep quality, and quality of life were collected preoperatively, at 1-7 days post-operation, 30 days post-operation, and 1 year post-operation. During the operation, blood, cerebrospinal fluid, and other biological samples from the patients were also collected.

No interventions assigned to this group

non-surgical subjects aged 65 years or older

For the non-surgical group patients, patients' basic information was collected, along with cognitive scales, sleep scales, and quality of life questionnaires.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1\) Surgical patients aged 65 or above or non-surgical subjects aged 65 or above. 2) Agree to participate in this study and sign the informed consent form.

Exclusion Criteria

1）Refused to participate in the study.

Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Ting Li

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ting Li, MD. PhD

Role: PRINCIPAL_INVESTIGATOR

Department of Anaesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China