A Predictive Study of Peripheral Blood Biomarkers on Postoperative Neurocognitive Dysfunction in Elderly Frail and Non-frail Patients Undergoing Gastrointestinal Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

338 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-04-01

Study Completion Date

2024-12-31

Brief Summary

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Perioperative neurocognitive impairment (PND) mainly includes acute postoperative delirium (POD) and persistent postoperative cognitive impairment (POCD), which are common postoperative complications in elderly patients. Perioperative neurocognitive impairment (PND) is attracting increasing attention, but its exact mechanism is still unclear. The diagnosis of PND lacks the gold standard, so it is difficult to determine the incidence rate. At present, the diagnosis is mainly conducted through the scale. Therefore, this study aims to explore the correlation between peripheral blood biomarkers and PND in elderly frail patients undergoing gastrointestinal surgery.

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Detailed Description

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Conditions

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Perioperative Neurocognitive Disorders Frail Elderly

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Frailty group

No interventions assigned to this group

Non-frailty group

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 65 years old
* American Society of Anesthesiologists (ASA) classification: grades I-IV
* Hospitalization time ≥ 3 days

Exclusion Criteria

* The revised version of the Cognitive Function Telephone Questionnaire (TICS-M) was used before surgery to determine cognitive impairment (TICS-M score ≤ 27 points)
* Refuse to participate
* Emergency surgical patients
* Central nervous system diseases (dementia, depression, etc.)
* Severe renal insufficiency (requiring dialysis)
* Long term use of psychotropic drugs (such as clozapine, risperidone, olanzapine, haloperidol, chlorpromazine, etc.)
* History of alcohol abuse or use of acetylcholine drugs
* The same patient can only be included once, regardless of whether the reason for the second surgery is related to the first cause

Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No