Biomarkers Associated With Postoperative Cognitive Dysfunction
NCT ID: NCT05464355
Last Updated: 2025-06-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
45 participants
OBSERVATIONAL
2023-01-05
2030-01-31
Brief Summary
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The causes of post operative cognitive dysfunction are poorly understood. Studies have been limited by a lack of biomarkers to predict which patients are at high risk of developing POCD. Research suggests silent strokes occurring during surgery and different sensitivities to anaesthetic medicines are associated with POCD.
The project consists of a feasibility study to investigate markers that might predict people over 65 years old getting POCD. The first biomarker is a non-invasive monitor of anaesthetics effects on brain function called electroencephalography (EEG): The investigators will identify which EEG patterns predict delirium within five days surgery. The second set of biomarkers are two blood tests of proteins that increase after strokes: these are neurofilament light chains and tau proteins. The investigators will establish if these can be used to predict having POCD up to one year after surgery and long term cognitive impairment up to 5 years after surgery.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Biomarker monitoring
Intraoperative electroencephalography recording
Intraoperative electroencephalography measurements, a non-invasive routine monitoring device used during anaesthesia to measure the brain's electrical activity
Neurofilament light chain measurement
Measurement of the level of neurofilament light chain in a blood sample
Tau protein measurement
Measurement of the level of tau protein in a blood sample
Interventions
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Intraoperative electroencephalography recording
Intraoperative electroencephalography measurements, a non-invasive routine monitoring device used during anaesthesia to measure the brain's electrical activity
Neurofilament light chain measurement
Measurement of the level of neurofilament light chain in a blood sample
Tau protein measurement
Measurement of the level of tau protein in a blood sample
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Having elective non-cardiac surgery under general anaesthesia
* Anticipated to have at least 48 hours of inpatient admission
* Able \& willing to give informed consent
Exclusion Criteria
* Presence of delirium prior to surgery
* Contraindication to use of EEG electrodes (e.g. known allergy to a component of the electrodes)
* Known history of severe traumatic brain injury
* Learning disability specifically with a known structural brain lesion
* Known history of dementia
* Participants undergoing operations on the carotid artery
65 Years
ALL
No
Sponsors
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Oxford University Hospitals NHS Trust
OTHER
University of Oxford
OTHER
Responsible Party
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Principal Investigators
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Martyn Ezra
Role: PRINCIPAL_INVESTIGATOR
University of Oxford
Locations
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Royal Berkshire NHS Foundation Trust
Reading, Berkshire, United Kingdom
Countries
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Other Identifiers
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302168
Identifier Type: OTHER
Identifier Source: secondary_id
Protocol version 13/06/2022
Identifier Type: OTHER
Identifier Source: secondary_id
PID16101
Identifier Type: -
Identifier Source: org_study_id
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