Identification of Factors Causing Postoperative Cognitive Dysfunction in Patients Undergoing Cardiac Surgery With CPB

NCT ID: NCT03641833

Last Updated: 2018-08-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

130 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-08-02

Study Completion Date

2021-09-30

Brief Summary

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The incidence of cognitive decline occurs in 53% of patients after cardiac surgery. Causes of POCD can be various: age, duration of cardiac bypass, medicaments and many others. The aim of this study is to determine factors causing postoperative cognitive dysfunction (POCD) and to identify which of them are most important

Detailed Description

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Prospective case-control study included patients undergoing cardiac at Clinic of Cardiac, Vascular and Thoracic Surgery, Lithuanian University of Health Sciences. Inclusion criteria is: 1) cardiac output \> 35%; 2) no agents affecting central nervous system; 3) no neuropathology; 5) no multiple organ dysfunction. Patients will have to perform mini mental state examination (MMSE), Trial making, addenbrooke tests before and 7 days after surgery. Brain biomarkers glial fibrillary acid protein (GFAP) and neurofilaments will be taken after induction, 24 and 48 hours after surgery. Transcranial Doppler will be performed to evaluate a.cerebri media blood flow speed during surgery.

After these test, the investigators are going to examine data about patient and operation, recognize factors causing POCD and identify the most important of them.

Conditions

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Postoperative Cognitive Dysfunction

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Interventions

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blood sample for brain biomarkers

Transcranial Doppler will be performed to evaluate a.cerebri media blood flow speed during surgery.

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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device

Eligibility Criteria

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Inclusion Criteria

* Coronary artery bypass grafting or/and heart valve surgery;
* Patients age\>18years
* Cardiac output \>35%

Exclusion Criteria

* Patient disagreement;
* Diseases causing cognitive dysfunction;
* Multi organic deficiency;
* Agents affecting central nervous system
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rasa Bukauskiene

OTHER

Sponsor Role lead

Responsible Party

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Rasa Bukauskiene

Physician anaesthesiologist

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Lithuanian University of Health Sciences

Kaunas, Outside US/Canada/Australia, Lithuania

Site Status RECRUITING

Countries

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Lithuania

Central Contacts

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Rasa Bukauskiene

Role: CONTACT

867111033

Edmundas Sirvinskas, Professor

Role: CONTACT

+37037326171

Facility Contacts

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Rasa Bukauskiene

Role: primary

867111033

Other Identifiers

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POCD-1

Identifier Type: -

Identifier Source: org_study_id

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