The Relationship Between Delirium and BDNF in Coronary Artery Bypass Graft Surgery

NCT ID: NCT06967779

Last Updated: 2025-05-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

107 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-07-01

Study Completion Date

2024-07-01

Brief Summary

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This study is aimed at finding a correlation between postoperative delirium occurrence, severity and duration after cardiac surgery and the level of brain-derived neurotrophic factor (BDNF) in plasma as a marker of brain injury induced by cardio-pulmonary by-pass and its association with genetic predisposition in patients undergoing coronary artery bypass grafting (CABG) carrying BDNF gene polymorphism (Val66Met).

Detailed Description

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Conditions

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Delirium - Postoperative BDNF CABG

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1. Age \> 18 years.
2. Planned coronary artery bypass grafting (CABG) procedure with the use of cardiopulmonary by-pass (CPB).
3. Ability to understand and sign an informed consent form.

Exclusion Criteria

1. Emergency surgery.
2. Previous known cognitive disorders: Mini Mental State Examination (MMSE) score \<15.
3. Baseline delirium (positive CAM test prior to surgery).
4. Diagnosis of psychiatric syndromes in the past - i.e. depression, dementia, psychosis or schizophrenia.
5. Inability to understand Polish language.
6. Inability to give and sign informed consent due to auditory or visual dysfunction.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pomeranian Medical University Szczecin

OTHER

Sponsor Role lead

Responsible Party

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Kacper Lechowicz

PhD student

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Uniwersytecki Szpital Kliniczny nr 2 PUM w Szczecinie

Szczecin, West Pomeranian Voivodeship, Poland

Site Status

Countries

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Poland

Other Identifiers

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delirium CABG

Identifier Type: -

Identifier Source: org_study_id

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