Plasma Proteomics in Patients With Postoperative Delirium

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-03-20

Study Completion Date

2025-01-01

Brief Summary

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Patients undergoing cardiac surgery were recruited. Baseline characteristics of all subjects were collected. The 3-minute Delirium diagnostic Scale (3D-CAM) was used to screen the POD group and non-POD group from the recruited subjects during the first 7 days after surgery. Peripheral blood samples were collected 1 day before surgery and 2 day after surgery. . Plasma was isolated from peripheral blood for subsequent proteomic analysis.

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Detailed Description

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Patients undergoing noncardiac surgery were recruited. Baseline characteristics of all subjects were collected. The 3-minute Delirium diagnostic Scale (3D-CAM) was used to screen the POD group and non-POD group from the recruited subjects during the first 7 days after surgery. Peripheral blood samples were collected 1 day before surgery and 2 day after surgery. Plasma was isolated from peripheral blood for subsequent proteomic analysis. To study the characteristics of proteins on a large scale, including protein expression levels, post-translational modifications, protein-protein interactions, etc., so as to obtain a comprehensive understanding of disease occurrence, cell metabolism and other processes at the protein level. Assessment of imbalanced protein expression in peripheral blood using protein profiling may allow us to better understand the pathological changes occurring at the molecular level of POD. Early detection of patients at high risk of POD can optimize perioperative management and promote rapid postoperative recovery.

Conditions

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Postoperative Delirium

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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POD group

According to the occurrence of postoperative delirium, the patients were divided into POD group and non-POD group

No interventions assigned to this group

non-POD group

According to the occurrence of postoperative delirium, the patients were divided into POD group and non-POD group

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age ≥65 years old, regardless of gender.
* The patient had clear consciousness and no cognitive impairment, and could cooperate with the investigation and follow-up.
* The ASA classification is I-Ⅲ.

Exclusion Criteria

* severe neurological or psychiatric disorders.
* drug and alcohol abuse.
* Patients with cognitive impairment caused by various reasons such as neuropsychiatric symptoms.

Minimum Eligible Age

65 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes