Correlation Between Plasma Oxidized Low Density Lipoprotein Levels And Postoperative Delirium

NCT ID: NCT03968887

Last Updated: 2019-05-30

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 300 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2019-05-20
• Study Completion Date: 2019-09-20

Brief Summary

Postoperative delirium (POD) refers to an acute neurocognitive disorder that occurs within 1 week after surgery or before discharge. Old age is one of the important risk factors for postoperative delirium. The incidence rate of the elderly is high, and the life span of human beings is increasing. Postoperative delirium has adverse effects on both short-term and long-term outcomes, including mortality, ability to work, and dependence on society.

Low-density lipoprotein (LDL) is a key molecule in the cholesterol transport mechanism and is easily oxidized to oxidized low-density lipoprotein (OxLDL). Oxidized low density lipoproteins are immunogenic and are also cytotoxic to endothelial cells. Some studies have shown that increased oxidative stress is one of the earliest changes in disease, and similar signs can be detected in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI), such as protein oxidation and lipids. An increase in the quality of the peroxidation index. For the study of anesthesiology, oxidative stress theory has long been recognized as one of the mechanisms of postoperative delirium. We have a hypothesis that plasma oxidized low-density lipoprotein levels are associated with postoperative delirium and can be used as an early warning marker for disease occurrence.

Based on clinical research data, we conducted a prospective cohort study to explore the correlation between plasma oxidized low-density lipoprotein levels and postoperative sputum, providing clinical prediction and diagnostic value.

Conditions

Postoperative Delirium

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Case group

Patients with postoperative delirium.

plasma oxidized low-density lipoprotein levels

Intervention Type: OTHER

Detection of plasma oxidized low-density lipoprotein levels

Control group

Patients who have not had postoperative delirium.

plasma oxidized low-density lipoprotein levels

Intervention Type: OTHER

Detection of plasma oxidized low-density lipoprotein levels

Interventions

plasma oxidized low-density lipoprotein levels

Detection of plasma oxidized low-density lipoprotein levels

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Surgical treatment was performed in our hospital under standard anesthesia.
• Patients in orthopedics, urology and general surgery.

Exclusion Criteria

• Patients with mental illness or taking psychotropic substances before surgery.
• Preoperative dementia or cognitive dysfunction.
• Unable to communicate and cooperate with patients due to coma, language barrier or end-stage disease before surgery.
• ASA greater or equal to 4.
• Patients who have undergone neurosurgery and cardiac vascular surgery.

• Minimum Eligible Age: 65 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Central Contacts

Lina Yu, MD

Role: CONTACT

zryulina@zju.edu.cn

+86 13958033387

Other Identifiers

2019-092

Identifier Type: -

Identifier Source: org_study_id