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Predictive Value of β2-microspheres for Postoperative Delirium

NCT ID: NCT03130231

Last Updated: 2018-12-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

184 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-10-01

Study Completion Date

2017-12-30

Brief Summary

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This study evaluated the predictive value of β2-microspheres for postoperative delirium (POD) in the elderly after orthopedic surgery. For this purpose, the levels of β2-microspheres in plasma and cerebrospinal fluid were compared between the POD and non-POD groups.

Detailed Description

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In this study, plasma and cerebrospinal fluid of the patients were collected to detect the levels of β2-microspheres before operation. Also, the patients were interviewed one day before the surgery and on postoperative days 1-3 by the Confusion Assessment Method and then divided them into POD and non-POD groups. The aim of the present study was to assess whether higher levels of β2-microspheres could predict the occurrence of POD.

Conditions

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Postoperative Delirium

Keywords

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Delirium β2-microspheres

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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POD group

POD group refers to the patients who were diagnosed to be delirious by the Confusion Assessment Method.

No interventions assigned to this group

Non-POD group

Non-POD refered to the patients who did not become delirious by the Confusion Assessment Method.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* ≥65 years old, American Standards AssociationⅠ-Ⅲ, undergoing orthopedic operations under spinal anesthesia

Exclusion Criteria

* decline to participate
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Zhongda Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jian-jun Yang

Director, Department of Anesthesiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jian-jun Yang

Role: PRINCIPAL_INVESTIGATOR

Zhongda Hospital

Locations

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Zhongda Hospital

Nanjing, Jiangsu, China

Site Status

Countries

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China

Other Identifiers

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199101026046

Identifier Type: -

Identifier Source: org_study_id