Study of the Correlation Between Specific Genes and Cognitive Dysfunction After Surgery
NCT ID: NCT01088100
Last Updated: 2011-01-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
279 participants
OBSERVATIONAL
2010-08-31
2011-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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Patients with POCD - cases
Out of the 976 patients included in the ISPOCD2 study (Abildstrom H, Christiansen M et al. Apolipoprotein E genotype and cognitive dysfunction after noncardiac surgery. Anesthesiology 2004;101:855-61) the 93 patients with POCD whose blood samples are stored will be included together with 2x93 controls (without POCD), who will be matched by type of surgery, age, education, ASA-score and sex.
Genotyping
Determination of 3 types of clock gene genotypes (HPER 4/4, 5/4, 5/5) on all blood samples
Patients without POCD - controls
Out of the 976 patients included in the ISPOCD2 study (Abildstrom H, Christiansen M et al. Apolipoprotein E genotype and cognitive dysfunction after noncardiac surgery. Anesthesiology 2004;101:855-61) the 93 patients with POCD whose blood samples are stored will be included together with 2x93 controls (without POCD), who will be matched by type of surgery, age, education, ASA-score and sex.
Genotyping
Determination of 3 types of clock gene genotypes (HPER 4/4, 5/4, 5/5) on all blood samples
Interventions
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Genotyping
Determination of 3 types of clock gene genotypes (HPER 4/4, 5/4, 5/5) on all blood samples
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* known disease of the CNS
* score less than 24/30 points in MMSE
40 Years
ALL
No
Sponsors
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Herlev Hospital
OTHER
Responsible Party
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Herlev Hospital
Principal Investigators
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Melissa V Hansen, MD
Role: PRINCIPAL_INVESTIGATOR
Herlev Hospital
Locations
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Herlev Hospital - Gastro unit
Herlev, , Denmark
Countries
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References
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Abildstrom H, Christiansen M, Siersma VD, Rasmussen LS; ISPOCD2 Investigators. Apolipoprotein E genotype and cognitive dysfunction after noncardiac surgery. Anesthesiology. 2004 Oct;101(4):855-61. doi: 10.1097/00000542-200410000-00009.
Moller JT, Cluitmans P, Rasmussen LS, Houx P, Rasmussen H, Canet J, Rabbitt P, Jolles J, Larsen K, Hanning CD, Langeron O, Johnson T, Lauven PM, Kristensen PA, Biedler A, van Beem H, Fraidakis O, Silverstein JH, Beneken JE, Gravenstein JS. Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction. Lancet. 1998 Mar 21;351(9106):857-61. doi: 10.1016/s0140-6736(97)07382-0.
Voigt Hansen M, Rasmussen LS, Jespersgaard C, Rosenberg J, Gogenur I. There is no association between the circadian clock gene HPER3 and cognitive dysfunction after noncardiac surgery. Anesth Analg. 2012 Aug;115(2):379-85. doi: 10.1213/ANE.0b013e318253d6b3. Epub 2012 Apr 27.
Other Identifiers
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MVH-01
Identifier Type: -
Identifier Source: org_study_id
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