Neurocognitive Function After Regional and General Anesthesia (245

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-09-30

Study Completion Date

2016-09-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Postoperative cognitive dysfunction (POCD) is a disease with restricted cognitive memory function and intellectual skills, which occurs after surgery with and without anesthesia. The POCD strongly depends on patient's age and the surgical operation type. The anesthesia procedure plays a pivotal role as well and regarding the current knowledge it is still uncertain which technique matches the lowest risk. Elevated stress level accompanied with regional anesthesia procedures are accused to cause POCD in elderly patients. The investigators address the question weather regional or general anesthesia leads to a pronounced POCD in dependence of stress incidence.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Risk Factors of POCD in General Anesthesia Patients Underwent Noncardiac and Non Neurological Procedures.

NCT04215263

Undergoing General Anaesthesia

COMPLETED

Retrospective Evaluation of POCD Data of Studies From KAI, Charité - Universitätsmedizin Berlin

NCT02832193

Postoperative Cognitive Dysfunction

RECRUITING

Whole Genome Single Nucleotide Polymorphisms in Elderly Patients With Postoperative Cognitive Dysfunction

NCT02864173

Postoperative Cognitive Dysfunction

COMPLETED

Cognitive Changes in Childs After Anesthesia / Surgery

NCT02658526

Behavioral

WITHDRAWN

Use of Electrophysiological Markers to Predict Post-operative Cognitive Dysfunction

NCT04512989

Cognitive Dysfunction

RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Postoperative cognitive dysfunction (POCD) is a disease with restricted cognitive memory function and intellectual skills, which occurs after surgery with and without anesthesia. The limiting cognitive ability leads to a lack of quality of life for a lot of patients. The POCD strongly depends on patient's age and the surgical operation type. In aged adults the incidence of POCD after one week following surgery is 25,8%. Risk factors for the development of a POCD is beside age less education and a reduced cognitive reserve. However, the anesthesia procedure plays a pivotal role as well and regarding the current knowledge it is still uncertain which technique matches the lowest risk. Elevated stress level accompanied with regional anesthesia procedures are accused to cause POCD in elderly patients. This fact leads to the question if a general anesthesia technique has a lower stress level and consequently leads to a reduced risk for a POCD development. Likewise the investigators address this hypothesis and analyze cognitive function following both anesthesia techniques separately in elderly patients.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Neurocognitive Function

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Regional Anesthesia

Patients with surgery in regional anesthesia.

Surgery

Intervention Type PROCEDURE

Cortisol Level Measurement

Intervention Type PROCEDURE

Neurocognitive Testing

Intervention Type PROCEDURE

General Anesthesia

Patients with surgery in general anesthesia.

Surgery

Intervention Type PROCEDURE

Cortisol Level Measurement

Intervention Type PROCEDURE

Neurocognitive Testing

Intervention Type PROCEDURE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Surgery

Intervention Type PROCEDURE

Cortisol Level Measurement

Intervention Type PROCEDURE

Neurocognitive Testing

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients within 50-85 years of age both gender.

Exclusion Criteria

* Patients under 50 years of age or older than 85 years of age.
* Preexisting neurological, neuropsychological deficits or diseases, e.g. cerebral insult or epilepsy.
* Preexisting neurological, neuropsychological medication, preexisting neuromuscular diseases.
* Alcohol- and drug abuse. Postoperative complications, pain and time shifts within the test protocol.

Minimum Eligible Age

50 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes