Postoperative Cognitive Dysfunction: Correlations With Olfactory Dysfunction and Related Gene Changes

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-12-31

Study Completion Date

2017-07-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

To study on the Postoperative Cognitive Dysfunction: Correlations With Olfactory Dysfunction and Related Gene Changes.To explore whether the olfactory dysfunction could be used as a predictor of POCD and to provide reference for POCD prevention, early detection and timely diagnosis and treatment.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Correlations of Epigenetic Changes With POCD in Surgical Patients

NCT02965235

Postoperative Cognitive Dysfunction

UNKNOWN

Clinical Outcomes in Elderly Patients With Preoperative Cognitive Dysfunction

NCT03143595

Cognitive Decline Age Problem Outcome

UNKNOWN

Biomarkers and Risk Factors for Perioperative Neurocognitive Dysfunction in Elderly Patients

NCT06044207

Perioperative Neurocognitive Dysfunction

RECRUITING

The Reliability and Validity of Perioperative Cognitive Test Network Platform for Monitoring Neurocognitive Changes

NCT06028568

Perioperative Neurocognitive Disorders

UNKNOWN

Postoperative Neurocognitive Disorders

NCT04244162

Obstructive Sleep Apnea Neurocognitive Disorders

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Postoperative Cognitive Dysfunction

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

study group

300 male and female patients undergoing non-cardiac surgery are enrolled at the Affiliated Hospital of Xuzhou Medical University \[Jiangsu China\]. Patients will be divided into POCD and non-POCD groups according to the scores of neuropsychological tests.

No interventions assigned to this group

control group

30 healthy volunteers are enrolled for calculating the Z-scores of study group.

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Between 60 to 85 years old;
* Undergoing non-cardiac and non-neurological surgery under general anesthesia;
* Expected hospital stay ≥5 days;
* American Society of Anesthesiologists class I or II.

Exclusion Criteria

* Mental or neurodegenerative diseases;
* History of severe trauma or surgery within one year;
* History of nasal or sinus illness or surgery;
* Cold or influenza within 3 weeks;
* Significant history of organ dysfunction;
* Previous neuropsychological testing;
* Difficulty to perform tests (including severe visual or auditory disorders);
* Mini-Mental State Examination (MMSE) \<24 points, \<20 points if the participant only attended elementary school, or \<17 points if the participant did not go to school.

Minimum Eligible Age

60 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes