The Effect of Heavy Smoking on Early Post Operative Cognitive Dysfunction in Senile Patients .

NCT ID: NCT05782946

Last Updated: 2024-08-19

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 110 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-04-01
• Study Completion Date: 2023-12-01

Brief Summary

Cognitive dysfunction is the impairment of mental process of perception, memory and information processing which allow the human to acquire knowledge and plan for the future . The etiology of Postoperative cognitive dysfunction (POCD) is unclear and seems to be multifactorial involving a combination of patient, surgical, anesthetic and environmental factors .It can be a manifestation of transient or permanent cerebral injury. While cognitive function tends to improve over months to years postoperatively in affected individuals, some proportion has seemingly permanent cognitive injury .

Detailed Description

Cognitive dysfunction is the impairment of mental process of perception, memory and information processing which allow the human to acquire knowledge and plan for the future . The etiology of Postoperative cognitive dysfunction (POCD) is unclear and seems to be multifactorial involving a combination of patient, surgical, anesthetic and environmental factors .It can be a manifestation of transient or permanent cerebral injury. While cognitive function tends to improve over months to years postoperatively in affected individuals, some proportion has seemingly permanent cognitive injury .

Most of the studies of POCD, however, have methodological difficulties, as pointed out by Newman and colleagues in their review of more than 40 studies . a major difficulty in trying to compare investigations or establish an incidence of POCD was the diversity in participants, types of surgery and anesthesia, methods of assessment, definition of POCD, and mode of analysis .

The number of tobacco smokers has been decreasing over the last decade in most Western countries, while the percentage of smokers is still increasing in some developing countries . Tobacco smoking is still one of the major causes of mortality and morbidity worldwide . In particular, it is well known that smoking is strongly associated with cardiovascular diseases, pulmonary diseases and cancer. In addition, it is also thought that smoking could increase the risk of poor postoperative outcomes, in ways including impaired wound healing ، infections and cardiopulmonary complications.

The definition of day surgery in Great Britain and Ireland is clear; the patient is admitted and discharged on the same day, with day surgery as the intended management. The term '23-h stay' is used in the United states healthcare system .

Conditions

Smoking and POCD

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• patients between 65 & 80 ys
• elective urological day-case surgery
• ASA physical status 1

Exclusion Criteria

• Patients not ASA1
• Patients receiving sedatives as midazolam.
• Pregnant Patients .
• Patients with cerebrovascular diseases .
• Patients with history of drug allergy or patients with substance abuse .
• Time of anesthesia less than 30 minute ,or more than one hour .
• Irrigation fluid rather than warm saline(40 degree ) or volume more than 1500 ml
• post- secondary Education level .

• Minimum Eligible Age: 65 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Beni-Suef University

OTHER

Sponsor Role: lead

Responsible Party

Mahmoud Hussein Bahr

Associated Professor of Anesthesiology and Surgical Intensive Care and pain medicine

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Mahmoud H Bahr

Role: PRINCIPAL_INVESTIGATOR

Faculty of Medicine Beni-Suef University Egypt

Locations

Faculty of medicine.Beni-suef university

Cairo, , Egypt

Countries

Egypt

Other Identifiers

FMBSUREC/12022023/Emam

Identifier Type: -

Identifier Source: org_study_id