Postoperative Neuroinflammation and Cognitive Dysfunction After Abdominal Surgery
NCT ID: NCT01881646
Last Updated: 2017-01-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
8 participants
INTERVENTIONAL
2013-06-30
2016-02-29
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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Positron emission tomography (PET)
Positron emission tomography (PET) using \[11C\]PBR28
Positron emission tomography (PET) using [11C]PBR28
Interventions
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Positron emission tomography (PET) using [11C]PBR28
Eligibility Criteria
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Inclusion Criteria
2. Lower abdominal surgery (hysterectomy/prostatectomy) under general anaesthesia
3. Obtained consent within 3 months before execution of the study.
Exclusion Criteria
2. Ongoing smoking, snuff or other nicotine compound treatment
3. Disabling neuropsychiatrical disorder (a Mini mental State Examination (MMSE) score ≤ 24, diagnosis of dementia, Mb Alzheimer, Mb Parkinson, schizophrenia, or mental depression) or other signs of significant cognitive decline.
4. History of stroke with neurological sequelae
5. Surgical procedure scheduled for regional anaesthesia.
6. Severe cardia and/or renal and/or hepatic impairment.
7. Coagulopathy.
8. Terminal phase of a chronic disease.
9. Patient on steroidal or non-steroidal anti-inflammatory drugs.
10. Admission B-Glucose \> 15 mmol/litre or poorly controlled diabetes mellitus.
11. Presumed uncooperativeness or legal incapacity.
12. Preoperative or later postoperative B-hemoglobin \< 90 g/L.
60 Years
75 Years
ALL
No
Sponsors
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University of Copenhagen
OTHER
Karolinska University Hospital
OTHER
Responsible Party
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Lars I Eriksson
Professor
Principal Investigators
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Lars I Eriksson, MD,PhD, Professor
Role: PRINCIPAL_INVESTIGATOR
Karolinska University Hospital and Karolinska Institutet
Other Identifiers
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POPE
Identifier Type: -
Identifier Source: org_study_id
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