Ketone Production With Acute Caffeine Intake

NCT ID: NCT02694601

Last Updated: 2023-07-27

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 10 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-01-31
• Study Completion Date: 2015-06-30

Brief Summary

Evaluate the effect of a caffeine supplement on the stimulation of lipolysis and the production of ketones in healthy adults (N=10).

Detailed Description

The aim of the study is to evaluate the effect of a caffeine supplement on the stimulation of lipolysis and the production of ketones in healthy adults (N=10). Two different doses of caffeine (2.5 mg/kg of BW and 5 mg/kg of BW) are compared. All the participants have to follow three sequential visits of four hours each, which included a breakfast with one of the doses (2.5 or 5 mg/kg) of the caffeine supplement or without any supplement (baseline) and repeated blood sampling in order to evaluate ketone concentrations.

Conditions

Healthy Adults

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Ketonemia following caffeine intake

Participants have to follow three sequential visits of four hours each, which included a breakfast with one of the doses (2.5 or 5 mg/kg) of the caffeine supplement or without any supplement (baseline) and repeated blood sampling in order to evaluate ketone concentrations.

Intervention 1: Control; no caffeine intake Intervention 2: Caffeine low dose (2.5 mg/kg of BW) Intervention 3: Caffeine high dose (5.0 mg/kg of MW)

Group Type: EXPERIMENTAL

Control

Intervention Type: DIETARY_SUPPLEMENT

4-hour visit with no caffeine is given during a standardize breakfast follow by repeated blood sampling.

Caffeine low dose

Intervention Type: DIETARY_SUPPLEMENT

4-hour visit with a dose of 2.5 mg/kg of caffeine is given during a standardize breakfast follow by repeated blood sampling.

Caffeine high dose

Intervention Type: DIETARY_SUPPLEMENT

4-hour visit with a dose of 5 mg/kg of caffeine is given during a standardize breakfast follow by repeated blood sampling.

Interventions

Control

4-hour visit with no caffeine is given during a standardize breakfast follow by repeated blood sampling.

Intervention Type: DIETARY_SUPPLEMENT

Caffeine low dose

4-hour visit with a dose of 2.5 mg/kg of caffeine is given during a standardize breakfast follow by repeated blood sampling.

Intervention Type: DIETARY_SUPPLEMENT

Caffeine high dose

4-hour visit with a dose of 5 mg/kg of caffeine is given during a standardize breakfast follow by repeated blood sampling.

Intervention Type: DIETARY_SUPPLEMENT

Other Intervention Names

CTL

Eligibility Criteria

Inclusion Criteria

• Healthy adults
• 18 years old and over

Exclusion Criteria

• Drinking more than 300 mg of caffeine per day
• Diabetes or prediabetes
• Abnormal liver and kidney function
• Uncontrolled dyslipidemia, blood pressure
• Use of drugs known to influence the metabolism of lipids and carbohydrates (steroid, beta-blockers, diuretics, insulin sensitizer, etc.)
• Severe inflammation or infection
• Pregnancy
• Smoking

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Université de Sherbrooke

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Stephen Cunnane, PhD

Role: PRINCIPAL_INVESTIGATOR

Research Centre on Aging - CSSS-IUGS - CIUSSS de l'Estrie - CHUS

Locations

Research Centre on Aging (CSSS-IUGS - CIUSSS de l'Estrie - CHUS)

Sherbrooke, Quebec, Canada

Countries

Canada

Other Identifiers

2014-441

Identifier Type: -

Identifier Source: org_study_id