The Effect of Coffee on Energy Expenditure and Caffeine Metabolism

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-10-23

Study Completion Date

2029-12-31

Brief Summary

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Obesity is a risk factor for chronic diseases, and improving energy expenditure is a way to prevent and treat obesity. The purpose of this project is to explore the relationship between the effect of coffee on energy expenditure and caffeine metabolism, which has important significance in the rational application of caffeine.

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Detailed Description

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The investigators will study the relationship between the effect of coffee on energy expenditure and caffeine metabolism. The investigators will recruit healthy participants. Participants will be forbidden to consume stimulant drinks such as coffee for 24 hours before the experiment. When the participants arrive at the lab on the day of the experiment, they will sign an informed consent form, a health history questionnaire and a daily coffee consumption questionnaire. The changes of drinking water/coffee on total energy expenditure (TEE), body temperature, heart rate, blood pressure, electrocardiogram, memory，cognition, sleep time and so on will be observed. The concentration of caffeine and its metabolites in the blood and urine will be measured by liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS).

Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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water

The participants will drink 200 ml water four times at 1 hour intervals.

Group Type EXPERIMENTAL

Caffeine content

Intervention Type OTHER

Participants will drink the same volume of water or coffee, caffeine content is 2mg/kg by body weight.

coffee

The participants will drink 200 ml coffee four times at 1 hour intervals.

Group Type EXPERIMENTAL

Caffeine content

Intervention Type OTHER

Participants will drink the same volume of water or coffee, caffeine content is 2mg/kg by body weight.

Interventions

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Caffeine content

Participants will drink the same volume of water or coffee, caffeine content is 2mg/kg by body weight.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy adults.
* Must be able to drink coffee.

Exclusion Criteria

* Diabetes.
* Hypoglycemia.
* Gout.
* Osteoporosis.
* Gastric ulcer.
* Pancreatitis.
* Intestinal obstruction.
* Blood phobia.
* Pathological hypo or hyper tension.
* Impaired glucose tolerance.
* Claustrophobia.
* HIV,etc.

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes