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Effects of Different Coffee Amounts on Energy Intake, Appetite, Glucose Metabolism and Inflammatory Markers

NCT ID: NCT01495754

Last Updated: 2011-12-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

33 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-01-31

Study Completion Date

2011-06-30

Brief Summary

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The purpose of the study is to investigate whether different doses of caffeinated coffee consumption has acute effects on subjective appetite feelings, energy intake and biochemical markers related to appetite, inflammation and glucose metabolism compared to water consumption in normal weight and overweight/obese participants.

Detailed Description

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Conditions

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Obesity Inflammation

Keywords

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coffee overweight/obese appetite energy intake inflammation glucose metabolism randomized controlled trial

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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coffee3

Group Type EXPERIMENTAL

coffee

Intervention Type OTHER

Comparison of different amounts of coffee

coffee6

Group Type EXPERIMENTAL

coffee

Intervention Type OTHER

Comparison of different amounts of coffee

water

Group Type PLACEBO_COMPARATOR

coffee

Intervention Type OTHER

Comparison of different amounts of coffee

Interventions

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coffee

Comparison of different amounts of coffee

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* apparently healthy
* habitual coffee drinkers (\>= 1cup of coffee/day)

Exclusion Criteria

* smokers
* restrained eaters (as this was evaluated using the Dutch Eating Behaviour Questionnaire)
* those who reported slimming or any other dietary regime
* athletes
* participants with a known diagnosis of either hypertension, diabetes, impaired glucose tolerance or a fasting blood glucose concentration above 125 mg/dl
* subjects on medication for hypertension or on medication known to alter glucose metabolism
* subjects who were on medication that may have an impact on appetite and sensory functioning or who reported a metabolic or
* endocrine disease,
* gastrointestinal disorders,
* a history of medical or surgical events that may have affected the study outcomes
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Harokopio University

OTHER

Sponsor Role lead

Responsible Party

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M. Yannakoulia

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mary Yannakoulia, PhD

Role: PRINCIPAL_INVESTIGATOR

Harokopio University

Locations

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Metabolic Unit of the Department of Nutrition and Dietetics, Harokopio University

Athens, , Greece

Site Status

Countries

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Greece

References

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Gavrieli A, Yannakoulia M, Fragopoulou E, Margaritopoulos D, Chamberland JP, Kaisari P, Kavouras SA, Mantzoros CS. Caffeinated coffee does not acutely affect energy intake, appetite, or inflammation but prevents serum cortisol concentrations from falling in healthy men. J Nutr. 2011 Apr 1;141(4):703-7. doi: 10.3945/jn.110.137323. Epub 2011 Feb 23.

Reference Type BACKGROUND
PMID: 21346100 (View on PubMed)

Perakakis N, Kokkinos A, Angelidi AM, Tsilingiris D, Gavrieli A, Yannakoulia M, Tentolouris N, Mantzoros CS. Circulating levels of five proglucagon-derived peptides in response to intravenous or oral glucose or lipids and to a mixed-meal in subjects with normal weight, overweight, and obesity. Clin Nutr. 2022 Sep;41(9):1969-1976. doi: 10.1016/j.clnu.2022.07.001. Epub 2022 Jul 19.

Reference Type DERIVED
PMID: 35961260 (View on PubMed)

Gavrieli A, Fragopoulou E, Mantzoros CS, Yannakoulia M. Gender and body mass index modify the effect of increasing amounts of caffeinated coffee on postprandial glucose and insulin concentrations; a randomized, controlled, clinical trial. Metabolism. 2013 Aug;62(8):1099-106. doi: 10.1016/j.metabol.2013.02.003. Epub 2013 Mar 15.

Reference Type DERIVED
PMID: 23498899 (View on PubMed)

Other Identifiers

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CofSt3

Identifier Type: -

Identifier Source: org_study_id