Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
14 participants
INTERVENTIONAL
2012-06-30
2013-12-31
Brief Summary
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This project aims to assess the effects of coffee consumption on glucose metabolism, using stable isotope tracer (13C-glucose) to explain the possible metabolic mechanisms involved on the reduced risk for T2DM.
Detailed Description
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The stable isotope minimal model protocol with oral glucose administration (Oral Dose Intravenous Label Experiment - ODILE) was performed. The use of ODILE methodology permits separation of the glucose absorbed and removed from the circulation increasing the accuracy and the effectiveness of glucose uptake and insulin sensitivity (Bluck et al., 2006).
Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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Coffee with Sugar
300mL of Coffee with 30g of Sugar
Coffee with Sugar
300mL of Coffee with 30g of Sugar
Coffee without Sugar
300mL of Coffee without Sugar
Coffee without Sugar
300mL of Coffee without Sugar
Decaffeinated Coffee without Sugar
300mL of Decaffeinated Coffee without Sugar
Decaffeinated Coffee without Sugar
300mL of Decaffeinated Coffee without Sugar
Water with Sugar
300mL of Water with 30g of Sugar
Water with Sugar
300mL of Water with 30g of Sugar
Water without Sugar
300mL of Water without Sugar
Water without Sugar
300mL of Water without Sugar
Interventions
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Coffee with Sugar
300mL of Coffee with 30g of Sugar
Coffee without Sugar
300mL of Coffee without Sugar
Decaffeinated Coffee without Sugar
300mL of Decaffeinated Coffee without Sugar
Water with Sugar
300mL of Water with 30g of Sugar
Water without Sugar
300mL of Water without Sugar
Eligibility Criteria
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Inclusion Criteria
* Body mass index (BMI) between 18.5 - 28.0 kg/m²;
* No weight changes (≥ 5 kg) in the last 3 months;
* Not take any pills/drugs that alter metabolism, appetite and sleep;
* Not have sleep disorders;
* Not have donated blood in the last 3 months;
* Regular breakfast consumption (≥100 kcal ingested up to 2 hours after waking ≥4x/week);
* Being a habitual coffee consumer (≥100mL ≥5x/week).
Exclusion Criteria
* Previous sudden fainting and convulsions;
* Any drugs and tobacco consumption;
* Consumption of more than 500mg of caffeine / day (5 cups of coffee, tea and cola soft drinks).
18 Years
50 Years
MALE
Yes
Sponsors
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Conselho Nacional de Desenvolvimento Científico e Tecnológico
OTHER_GOV
MRC Human Nutrition Research
OTHER_GOV
University of Brasilia
OTHER
Responsible Party
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Caio Eduardo Gonçalves Reis
Principal Investigator
Principal Investigators
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Leslie JC Bluck, PhD
Role: STUDY_CHAIR
MRC Human Nutrition Research
Teresa HM da Costa, PhD
Role: STUDY_DIRECTOR
University of Brasilia
Caio EG Reis, MSc
Role: PRINCIPAL_INVESTIGATOR
University of Brasilia
Locations
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Laboratório de Bioquímica da Nutrição, Núcleo de Nutrição e Medicina Tropical, Universidade de Brasília
Brasília, Federal District, Brazil
Countries
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References
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Bluck LJ, Clapperton AT, Coward WA. A stable isotope minimal model protocol with oral glucose administration. Rapid Commun Mass Spectrom. 2006;20(3):493-8. doi: 10.1002/rcm.2326.
Other Identifiers
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GliCafé
Identifier Type: -
Identifier Source: org_study_id