Quantification of Ketosis After Intake of Coconut Oil and Caprylic Acid-With and Without Glucose-After a 12-hour Fast
NCT ID: NCT03904433
Last Updated: 2019-05-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
15 participants
INTERVENTIONAL
2018-08-24
2018-10-12
Brief Summary
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Detailed Description
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The aim of this study is to assess ketosis, as a combined effect of an extended overnight fast, and intake of coconut oil or C8, and to study how ketosis is affected by simultaneous glucose intake. Sunflower oil is used as control, expected to not break fasting ketosis, although not being ketogenic in itself. Some sunflower oil is also added to C8 to make that arm isocaloric with coconut oil, with a roughly similar proportion of MCT.
Coffee with cream will be used as a vehicle, and although coffee has been reported to be mildly ketogenic, this effect is expected to be negligible and equally distributed between arms.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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1. Sunflower oil
Sunflower oil (30 g)
Sunflower oil
Sunflower oil given in coffee with cream
2. Caprylic acid
Caprylic acid (20 g) + Sunflower oil (10 g)
Caprylic acid
Caprylic acid given in coffee with cream
Sunflower oil
Sunflower oil given in coffee with cream
3. Caprylic acid + Glucose
Caprylic acid (20 g) + Sunflower oil (10 g) + Glucose (50 g)
Caprylic acid
Caprylic acid given in coffee with cream
Sunflower oil
Sunflower oil given in coffee with cream
Glucose
Glucose dissolved in water
4. Coconut oil
Coconut oil (30 g)
Coconut oil
Coconut oil given in coffee with cream
5. Coconut oil + Glucose
Coconut oil (30 g) + Glucose (50 g)
Coconut oil
Coconut oil given in coffee with cream
Glucose
Glucose dissolved in water
6. Coconut oil + Caprylic acid
Coconut oil (30 g) + Caprylic acid (20 g)
Coconut oil
Coconut oil given in coffee with cream
Caprylic acid
Caprylic acid given in coffee with cream
Interventions
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Coconut oil
Coconut oil given in coffee with cream
Caprylic acid
Caprylic acid given in coffee with cream
Sunflower oil
Sunflower oil given in coffee with cream
Glucose
Glucose dissolved in water
Eligibility Criteria
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Inclusion Criteria
* Written informed consent
Exclusion Criteria
* Weight \<50 kg
* Diagnosed diabetes
* History of heart disease
* History of disease related to internal organs or metabolism
* Experience of "sensitive gut", or known intolerance to the test ingredients
* Medication expected to affect glucose- or lipid-metabolism
* Fasting during study or one month before
* High intensity physical activity \> 3 times/week
* Dementia
* Severe psychiatric conditions
* Hb\<125 g/L
* Participation in other lifestyle intervention last 6 months
65 Years
75 Years
ALL
Yes
Sponsors
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Karolinska Institutet
OTHER
Responsible Party
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Miia Kivipelto
Professor, MD, PhD
Principal Investigators
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Miia Kivipelto, Professor
Role: PRINCIPAL_INVESTIGATOR
Karolinska Institutet
Locations
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Karolinska Institutet
Solna, Stockholm County, Sweden
Countries
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References
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Norgren J, Daniilidou M, Kareholt I, Sindi S, Akenine U, Nordin K, Rosenborg S, Ngandu T, Kivipelto M, Sandebring-Matton A. Serum proBDNF Is Associated With Changes in the Ketone Body beta-Hydroxybutyrate and Shows Superior Repeatability Over Mature BDNF: Secondary Outcomes From a Cross-Over Trial in Healthy Older Adults. Front Aging Neurosci. 2021 Aug 20;13:716594. doi: 10.3389/fnagi.2021.716594. eCollection 2021.
Norgren J, Sindi S, Sandebring-Matton A, Kareholt I, Daniilidou M, Akenine U, Nordin K, Rosenborg S, Ngandu T, Kivipelto M. Ketosis After Intake of Coconut Oil and Caprylic Acid-With and Without Glucose: A Cross-Over Study in Healthy Older Adults. Front Nutr. 2020 Apr 15;7:40. doi: 10.3389/fnut.2020.00040. eCollection 2020.
Other Identifiers
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CC1
Identifier Type: -
Identifier Source: org_study_id
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