Ketone Esters for Appetite, Cognition, and Cardiovascular Function in Individuals With Obesity and Insulin Resistance
NCT ID: NCT05651243
Last Updated: 2024-05-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
NA
20 participants
INTERVENTIONAL
2022-12-28
2023-12-29
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
The main question\[s\] it aims to answer are:
* Does taking the ketone supplement reduce appetite and improve cognition?
* How does the ketone supplement alter metabolism and cardiovascular function?
Participants will be asked to consume a randomly assigned ketone ester supplement or a placebo and testing will be done to see how the supplement affects the following compared to a placebo:
* appetite,
* cognition,
* metabolism
* cardiovascular function
Researchers will compare individuals with obesity and insulin resistance to individuals with normal weight and no insulin resistance to see if the ketone supplement affects groups differently.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Effects of Ketone Monoesters on Brain Function
NCT06395051
Impact of Exogenous Ketones on Indices of Keto-Adaptation in Obese Subjects on Weight Reducing Diets.
NCT06449287
Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate
NCT06044935
The Effect of Ketone Ester Supplementation and Ketogenic Diet on Brain Plasticity in Overweight/Obese Adults
NCT06368297
Exogenous Ketosis in a Fed and a Fasted State
NCT06320522
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
CROSSOVER
TREATMENT
SINGLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Ketone Ester
Oral ketone ester supplement
Ketone Ester Supplement
Oral ingestion of a ketone supplement combined with a flavoring agent and diluted in water
Placebo
Taste and viscosity matched placebo
Placebo
Oral ingestion of cellulose combined with a flavoring agent and diluted in water
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Ketone Ester Supplement
Oral ingestion of a ketone supplement combined with a flavoring agent and diluted in water
Placebo
Oral ingestion of cellulose combined with a flavoring agent and diluted in water
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Presence of metabolic sydnrome
Control Participant Eligibility:
* A waist circumference of \< 102 cm for males and \< 88 cm for females, and
* No indication of metabolic syndrome
Exclusion Criteria
* Breastfeeding or lactating
* Missing any limbs or part of a limb
* Having a substantial amount of metal implants (metal plates or complete joint replacements)
* Having a pacemaker or any other electrical implant
* Type I diabetes
* Gestational diabetes
* Taking insulin
* Any history of severe traumatic brain injury or mild traumatic brain injury within the last two years
* Kidney disease
* Liver disease
* Thyroid disease
* Any diagnosed neurological or neurodegenerative diseases
* Any surgeries that would impact swallowing and/or digestion
* Being on a ketogenic diet or having been on a ketogenic diet in the last 6 months
* Having received ionizing radiation from a medical procedure within the last 30 days
* Being on a medically prescribed diet
18 Years
50 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
University of Southern Mississippi
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Austin Graybeal
Assistant Professor
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Austin J Graybeal, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Southern Mississippi
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
University of Southern Mississippi - School of Kinesiology and Nutrition
Hattiesburg, Mississippi, United States
Countries
Review the countries where the study has at least one active or historical site.
References
Explore related publications, articles, or registry entries linked to this study.
Stavres J, Aultman RS, Brandner CF, Vallecillo-Bustos A, Compton AT, Swafford SH, Newsome TA, Graybeal AJ. Influence of exogenous ketosis on spontaneous cardiovagal baroreflex gain and blood pressure responses to isometric handgrip in individuals with metabolic syndrome: a placebo-controlled pilot study. Eur J Appl Physiol. 2025 Jul 31. doi: 10.1007/s00421-025-05921-z. Online ahead of print.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
22-877
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.