Volatile Versus Propofol Anesthesia in OPCAB

NCT ID: NCT02222142

Last Updated: 2014-08-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1080 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-01-31

Study Completion Date

2012-12-31

Brief Summary

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Off pump coronary artery bypass graft (OPCAB) still requires myocardial protection owing to intermittent regional ischemic episode. The investigators retrospectively evaluated the cardioprotective and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB.

Detailed Description

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Several experimental and clinical researches have suggested that volatile anesthetics may reduce mortality in cardiac surgery owing to its preconditioning induced cardioprotective effect. Off-pump coronary artery bypass graft (OPCAB) surgery still requires cardioprotective strategies due to coronary hypoperfusion during anastomosis. The aim of this study was to evaluate the possible cardioprotective effect and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB using propensity matching.

Conditions

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Off Pump Coronary Artery Bypass Graft

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Isoflurane group

Isoflurane inhalational anesthesia during OPCAB

Isoflurane

Intervention Type DRUG

Comparison between isoflurane and propofol, Retrospective study

Propofol group

Total intravenous anesthesia with propofol during OPCAB

No interventions assigned to this group

Interventions

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Isoflurane

Comparison between isoflurane and propofol, Retrospective study

Intervention Type DRUG

Other Intervention Names

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inhalational anesthetics

Eligibility Criteria

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Inclusion Criteria

* OPCAB

Exclusion Criteria

* On pump conversion
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Samsung Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Jong Hwan Lee

Assistant professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Samsung medical center

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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2013-09-127

Identifier Type: -

Identifier Source: org_study_id

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