Organ Protection With Sevoflurane Postconditioning After Cardiac Surgery With Cardiopulmonary Bypass
NCT ID: NCT00924222
Last Updated: 2011-10-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
120 participants
INTERVENTIONAL
2007-10-31
2009-12-31
Brief Summary
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Sedation of patients on ICU after cardiac surgery with cardiopulmonary bypass with either propofol or sevoflurane. Evaluation of organ function and inflammatory mediators in the blood.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Sevoflurane
Sevoflurane
Sedation with sevoflurane
Propofol
Sedation on intensive care unit with propofol
Propofol
Sevoflurane
Sedation with sevoflurane
Propofol
Sedation on intensive care unit with propofol
Interventions
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Sevoflurane
Sedation with sevoflurane
Propofol
Sedation on intensive care unit with propofol
Eligibility Criteria
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Inclusion Criteria
* Ejection fraction (EF) = 30%
* Canadian Cardiovascular Society (CCS) classification = 3
* Ages 18 to 90 years old
Exclusion Criteria
* Renal disease and/ or creatinine-clearance \< 60 ml/min
* Previous cardiac surgery
* Emergency procedures
* Postoperative intra aortic balloon pump (IABP) requirement
* Myocardial infarction \< 7d
* Steroid treatment
* Insulin-dependent diabetes
* Pregnancy
18 Years
90 Years
ALL
No
Sponsors
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University of Zurich
OTHER
Responsible Party
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Principal Investigators
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01 Studienregister MasterAdmins
Role: STUDY_DIRECTOR
UniversitaetsSpital Zuerich
Locations
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Zurich, , Switzerland
Countries
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References
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Steurer MP, Steurer MA, Baulig W, Piegeler T, Schlapfer M, Spahn DR, Falk V, Dreessen P, Theusinger OM, Schmid ER, Schwartz D, Neff TA, Beck-Schimmer B. Late pharmacologic conditioning with volatile anesthetics after cardiac surgery. Crit Care. 2012 Oct 14;16(5):R191. doi: 10.1186/cc11676.
Other Identifiers
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IFA-5-2007
Identifier Type: -
Identifier Source: org_study_id