Remimazolam and Propofol on the Left Ventricular Strain During Anesthesia Induction for Non-cardiac Surgery
NCT ID: NCT05412914
Last Updated: 2023-10-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
40 participants
INTERVENTIONAL
2023-01-26
2024-01-01
Brief Summary
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LV-GLS is analyzed by using speckle tracking technique of transthoracic echocardiography.
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Detailed Description
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Remimazolam or propofol is randomly administered for anesthesia induction (Group-R and Group-P, respectively) The changes of LV-GLS are analyzed by using using speckle tracking technique. For this study, 2-dimensional of transthoracic echocardiography LV images (apical 2-chamber, 3-chamber, and 4-chamber views) are recorded and stored before administration of remimazolam/propofol (T0), 2 minutes after the administration (T2), 4 minutes after the administration (T4), and 6 minutes after the administration (T6).
After the completion of the study, LV-GLS values at T0, T2, T4 and T6 are determined by the off-line analyses of the recorded and stored 2D-images.
For the off-line determination of LV-GLS, an automated software of speckle-tracking technique (Qapp Autostrain-LV™, Philips) is employed.
The primary measure:
Inter-group comparison of the lowest LV-GLS value out of LV-GLS values at T2, T4, and T6.
The secondary measures:
Inter-group comparisons of the LV-GLS values at T0, T2, T4 and T8. Intra-group comparisons of the LV-GLS value at T0 vs. those at T2, T4 and T8
Conditions
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Study Design
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RANDOMIZED
PARALLEL
DIAGNOSTIC
TRIPLE
Study Groups
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Remimazolam
remimazolam infusion
Remimazolam infusion
Remimazolam infusion for anesthesia induction
Propofol
propofol infusion
Propofol infusion
Propofol infusion for anesthesia induction
Interventions
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Remimazolam infusion
Remimazolam infusion for anesthesia induction
Propofol infusion
Propofol infusion for anesthesia induction
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* no left ventricular regional wall motion abnormality
Exclusion Criteria
* unfavorable airway
* hypotension requiring inotropic support
20 Years
ALL
Yes
Sponsors
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Konkuk University Medical Center
OTHER
Responsible Party
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Tae-Yop Kim, MD PhD
Professor, Department of Anesthesiology
Principal Investigators
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Tae-Yop Kim, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Konkuk University Medical Center
Locations
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Konkuk University Medical Center
Seoul, , South Korea
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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20210000-01
Identifier Type: -
Identifier Source: org_study_id
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