Propofol Effects on Mitral Valve Annular Velocity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is primarily to determine the effects of propofol at different concentration on the mitral valve annulus by using Tissue Doppler Imaging

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Propofol Induction's Effect on Cardiac Function

NCT02408341

This Study Was Focused to Evaluate Feasibility of Doppler Tissue Monitoring During the Induction Anesthesia, and Evaluate Routine Propofol Induction's Effect on Myocardial Tissue Motion, Using Non-invasive Doppler Tissue and 2D Speckle Tracking Imaging. This is the First Study, to Our Knowledge, Which Has Evaluated the Possible Impact of Propofol Induction on LV Function.

COMPLETED

Remimazolam and Propofol on the Left Ventricular Strain During Anesthesia Induction for Non-cardiac Surgery

NCT05412914

Surgical Procedure, Unspecified

UNKNOWN PHASE4

Study of Rocuronium Onset Time According to Remifentanil Infusion

NCT01030510

Anesthesia

COMPLETED NA

Effect of Propofol on Renal Injury in Patients Undergoing Valvular Heart Surgery

NCT01384643

Heart Valve Disease

COMPLETED PHASE4

Target Controlled Infusion of Etomidate or Propofol for Anesthesia of Thoracoscopic Mitral Valve Replacement Surgery

NCT02644980

Delirium Hemodynamic Instability

UNKNOWN PHASE4

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The purpose of this study is to evaluate the effects of different concentration of propofol on patients who are undergoing cardiac surgery. The patients will receive infusion remifentanil 0.5mcg/kg/min with different target-site propofol concentration namely 1.0ng/ml, 2.0ng/ml and 3.0ng/ml. Tissue Doppler Imaging by transesophageal echocardiography will be done to assess the changes in cardiac function.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Valvular Heart Disease Coronary Artery Disease

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Propofol 1.0mcg

Propofol dosage titration, comparison of the effect of different concentration of propofol to the myocardial performances, namely at 1.0mcg/ml using target controlled infusion.

Group Type EXPERIMENTAL

Propofol 1.0mcg

Intervention Type DRUG

Propofol dosage titration to achieve effect site concnetration at 1.0 mcg/ml using target controlled infusion.

Propofol 2.0mcg

Propofol dosage titration, comparison of the effect of different concentration of propofol to the myocardial performances, namely at 2.0mcg/ml using target controlled infusion.

Group Type EXPERIMENTAL

Propofol 2.0mcg

Intervention Type DRUG

Propofol dosage titration to achieve effect site concnetration at 2.0 mcg/ml using target controlled infusion.

Propofol 3.0mcg

Propofol dosage titration, comparison of the effect of different concentration of propofol to the myocardial performances, namely at 3.0mcg/ml using target controlled infusion.

Group Type EXPERIMENTAL

Propofol 3.0mcg

Intervention Type DRUG

Propofol dosage titration to achieve effect site concnetration at 3.0 mcg/ml using target controlled infusion

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Propofol 1.0mcg

Propofol dosage titration to achieve effect site concnetration at 1.0 mcg/ml using target controlled infusion.

Intervention Type DRUG

Propofol 2.0mcg

Propofol dosage titration to achieve effect site concnetration at 2.0 mcg/ml using target controlled infusion.

Intervention Type DRUG

Propofol 3.0mcg

Propofol dosage titration to achieve effect site concnetration at 3.0 mcg/ml using target controlled infusion

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Fresofol (2% propofol, Fresinius Kabi) Fresofol (2% propofol, Fresinius Kabi) Fresofol (2% propofol, Fresinius Kabi)

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

patients undergoing cardiac surgery

Exclusion Criteria

low ejection fraction \< 50% on transthoracic echocardiography atrial fibrillation pacemaker pericardial and infiltrative myocardial disease mitral annular calcification, surgical rings, prosthetic mitral valve lateral left ventricular wall motion abnormality oesophageal abnormality history of extensive radiation to the mediastinum upper gastrointestinal bleeding

Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No