Desflurane Versus Propofol Anesthesia for Off-Pump CABG
NCT ID: NCT00528515
Last Updated: 2008-05-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
80 participants
INTERVENTIONAL
2007-02-28
2008-03-31
Brief Summary
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1. hemodynamic parameters during and after the operation,
2. pulmonary gas exchange, need for mechanical ventilation and for ICU and intrahospital stay,
3. release of heart muscle injury markers in response to surgery and intraoperative ischaemia,
4. inflammatory response to the operation.
We suspect that insufflation anesthesia with desflurane may be superior to intravenous anesthesia with propofol.
Detailed Description
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After induction of anesthesia a Swan-Ganz catheter for continuous cardiac output, right ventricle end diastolic volume and blood saturation measurements will be introduced through the internal jugular vein. A transesophageal echocardiography probe will be placed additionally for the Tei-index measurement.
Hemodynamic parameters will be recorded at the following time points:
* before induction
* after induction
* during trachea intubation
* before skin incision
* 3 Min. after skin incision
* after sternotomy
* before heart positioning for graft placing
* before finishing placing each distal anastomoses
* 10, 20, 30, 40 min after placing the last anastomoses
* 10 Min. after admission to ICU, 6, 12, 18 and 24 hours after surgery.
* TEE measurements will be obtained after sternotomy and 20 Min after placing the last distal anastomoses.
The results will be compared while using the parametric ANOVA test for normally distributed continuous data or the nonparametric Kruskal-Wallis/Wilcoxon-U test for categoric or inhomogeneous distributed continuous data.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
SINGLE
Study Groups
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1
propofol
Diprivan (propofol), Astra-Zeneca
continuous intravenous infusion with a dose of 3-5 mg/kg/h
2
desflurane
Suprane (desflurane), Baxter
a vapor concentration of 3-7 vol% is maintained with use of vaporizer and under control of arterial blood pressure, heart rate, and BIS index.
Interventions
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Diprivan (propofol), Astra-Zeneca
continuous intravenous infusion with a dose of 3-5 mg/kg/h
Suprane (desflurane), Baxter
a vapor concentration of 3-7 vol% is maintained with use of vaporizer and under control of arterial blood pressure, heart rate, and BIS index.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Elective surgery
* Signed informed consent
Exclusion Criteria
* Serum creatinine \> 2 mg/dL
* Emergency surgery
* Denied consent
18 Years
75 Years
ALL
No
Sponsors
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Medical University of Gdansk
OTHER
Responsible Party
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Medical University of Gdańsk, Dept. of Cardiac Anesthesiology
Principal Investigators
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Romuald Lango, M.D., Ph.D.
Role: STUDY_DIRECTOR
Medical University of Gdańsk, Department of Cardiac Anesthesiology
Locations
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Department of Cadiac Anesthesiology, Medical University of Gdańsk
Gdansk, , Poland
Countries
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References
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Xia Z, Luo T. Sevoflurane or desflurane anesthesia plus postoperative propofol sedation attenuates myocardial injury after coronary surgery in elderly high-risk patients. Anesthesiology. 2004 Apr;100(4):1038-9; author reply 1039-40. doi: 10.1097/00000542-200404000-00050. No abstract available.
Tritapepe L, Landoni G, Guarracino F, Pompei F, Crivellari M, Maselli D, De Luca M, Fochi O, D'Avolio S, Bignami E, Calabro MG, Zangrillo A. Cardiac protection by volatile anaesthetics: a multicentre randomized controlled study in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass. Eur J Anaesthesiol. 2007 Apr;24(4):323-31. doi: 10.1017/S0265021506001931. Epub 2006 Dec 8.
Guarracino F, Landoni G, Tritapepe L, Pompei F, Leoni A, Aletti G, Scandroglio AM, Maselli D, De Luca M, Marchetti C, Crescenzi G, Zangrillo A. Myocardial damage prevented by volatile anesthetics: a multicenter randomized controlled study. J Cardiothorac Vasc Anesth. 2006 Aug;20(4):477-83. doi: 10.1053/j.jvca.2006.05.012.
De Hert SG, Cromheecke S, ten Broecke PW, Mertens E, De Blier IG, Stockman BA, Rodrigus IE, Van der Linden PJ. Effects of propofol, desflurane, and sevoflurane on recovery of myocardial function after coronary surgery in elderly high-risk patients. Anesthesiology. 2003 Aug;99(2):314-23. doi: 10.1097/00000542-200308000-00013.
Mrozinski P, Lango R, Biedrzycka A, Kowalik MM, Pawlaczyk R, Rogowski J. Comparison of haemodynamics and myocardial injury markers under desflurane vs. propofol anaesthesia for off-pump coronary surgery. A prospective randomised trial. Anaesthesiol Intensive Ther. 2014 Jan-Mar;46(1):4-13. doi: 10.5603/AIT.2014.0002.
Related Links
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Other Identifiers
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AMG-NKEBN/364-A/2005
Identifier Type: -
Identifier Source: org_study_id