Comparison of Effects of Oxycodone and Sufentanil on Cardiovascular Stress Induced by Tracheal Intubation in the Patients With Coronary Heart Disease Undergoing Major Noncardiac Surgery

NCT ID: NCT04121416

Last Updated: 2019-10-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-04-01

Study Completion Date

2019-09-19

Brief Summary

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To evaluate the effect of oxycodone and sufentanil in preventing cardiovascular responses to tracheal intubation in the patients with coronary heart disease (CHD).

Detailed Description

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Laryngoscopy and tracheal intubation can provoke an increase of blood pressure (BP) and/or HR \[1.2\]. This hemodynamic stress may lead to an imbalance between myocardial oxygen consumption and supply and therefore induce myocardial ischemia, which may be endurable in the patients with normal cardiovascular condition but is potential harmful to the patients with coronary heart disease. Thus it is critical to attenuate the cardiovascular stress induced by laryngoscopy and endotracheal intubation in the high risk patients.

Conditions

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Cardiovascular

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Oxycodone group

Group Type EXPERIMENTAL

Oxycodone 10mg

Intervention Type DRUG

induction with 0.3mg/kg of oxycodone in general anesthesia

Sufentanil group

Group Type EXPERIMENTAL

Sufentanil

Intervention Type DRUG

induction with 0.3 µg/kg of Sufentanil in general anesthesia

Interventions

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Oxycodone 10mg

induction with 0.3mg/kg of oxycodone in general anesthesia

Intervention Type DRUG

Sufentanil

induction with 0.3 µg/kg of Sufentanil in general anesthesia

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

The coronary angiography from each patient showed that lesions exist in at least one main coronary artery

Exclusion Criteria

a history of reactive airway disease, gastroesophageal reflux, morbid obesity, a known or predicted difficult airway
Minimum Eligible Age

60 Years

Maximum Eligible Age

85 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Shengjing Hospital

OTHER

Sponsor Role lead

Responsible Party

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Yanchao Yang

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Junchao Zhu

Role: STUDY_DIRECTOR

Shengjing Hospital

Locations

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shengjing hospital of China medical university

Shenyang, Liaoning, China

Site Status

Countries

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China

Other Identifiers

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Oxycodone VS Sufentanil

Identifier Type: -

Identifier Source: org_study_id

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