The Effect of Oxycodone Hydrochloride on CRBD After TURBT Under General Anesthesia
NCT ID: NCT05510986
Last Updated: 2022-08-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
196 participants
INTERVENTIONAL
2022-10-01
2024-11-01
Brief Summary
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Detailed Description
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Oxycodone Hydrochloride is a strong opioid receptor agonist used in clinic at present. It has certain advantages in the regulation of visceral pain and can produce analgesic effect without causing restlessness, gastrointestinal motility inhibition and respiratory inhibition through stimulating the μ and κ opioid receptor simultaneously. However, the effect of Oxycodone Hydrochloride on catheter-related bladder discomfort in patients undergoing transurethral resection of bladder tumor after general anesthesia is still unknown. The purpose of this study is to explore whether Oxycodone Hydrochloride via intravenous injection could reduce the incidence of CRBD in patients undergoing transurethral resection of bladder tumor after general anesthesia and could not increase other complications during the recovery period of general anesthesiathe.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Fentanyl group
Drugs
Fentanyl group
Dilute fentanyl hydrochloride injection (1ml:0.1mg) with 0.9% normal saline to 10μg/ml, 1μg/kg fentanyl is slowly injected intravenously 10 minutes before the end of the operation, and the administration speed is not less than 5 minutes.
Oxycodone Hydrochloride group
Drugs
Oxycodone Hydrochloride group
Dilute Oxycodone Hydrochloride injection (1ml:10mg) with 0.9% normal saline to
1mg/ml, 0.1mg/kg Oxycodone Hydrochloride is slowly injected intravenously 10 minutes before the end of the operation, and the administration speed is not less than 5 minutes.
Interventions
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Fentanyl group
Dilute fentanyl hydrochloride injection (1ml:0.1mg) with 0.9% normal saline to 10μg/ml, 1μg/kg fentanyl is slowly injected intravenously 10 minutes before the end of the operation, and the administration speed is not less than 5 minutes.
Oxycodone Hydrochloride group
Dilute Oxycodone Hydrochloride injection (1ml:10mg) with 0.9% normal saline to
1mg/ml, 0.1mg/kg Oxycodone Hydrochloride is slowly injected intravenously 10 minutes before the end of the operation, and the administration speed is not less than 5 minutes.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* ASA I - III;
* Plan to perform transurethral resection of bladder tumor under general anesthesia; (
* Agree to participate in this study and sign the informed consent form.
Exclusion Criteria
* Emergency surgery;
* Catheter was indwelling before operation;
* Taking opioids for a long time before operation;
* Previous history of schizophrenia, epilepsy, Parkinson's disease or myasthenia gravis;
* Unable to communicate due to coma, severe dementia or language disorder before operation;
* Critical condition (ASA grade ≥ IV before operation); Severe renal function damage (requiring renal replacement therapy); Severe liver function damage (child Pugh grade C); Acute stage of chronic obstructive pulmonary disease, severe asthma, severe pulmonary heart disease;
* History of opioid allergy.
18 Years
ALL
No
Sponsors
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General Hospital of Ningxia Medical University
OTHER
Responsible Party
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Principal Investigators
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Ni xinli, MD
Role: STUDY_CHAIR
General Hospital of Ningxia Medical University
Locations
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General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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lingzi-2022-1
Identifier Type: -
Identifier Source: org_study_id
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