Anesthesia and Lymphocytes Apoptosis

Study Results

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

105 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-10-31

Study Completion Date

2014-10-31

Brief Summary

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Most researches revealed that volatile anesthetic sevoflurane has a more marked cardioprotective effect against ischemia compared with intravenous agent propofol.However, propofol has been suggested to be more benefit for attenuation of surgery-induced immunosuppression.Thus, the aim of this study was to investigate under the specific OPCAB surgical stress, the influence of 3 established anesthetic techniques: sevoflurane, propofol and combine of sevoflurane and propofol maintained anesthesia on the apoptosis of circulating lymphocytes.

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Detailed Description

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Conditions

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Anesthesia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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Sevoflurane

Group Type EXPERIMENTAL

Sevoflurane

Intervention Type DRUG

anesthesia was maintained with sevoflurane (end-tidal concentration 1.0-1.5 minimum alveolar concentration)

Propofol

Group Type EXPERIMENTAL

Propofol

Intervention Type DRUG

anesthesia was maintained with propofol (2-4 μg/ml via target-controlled infusion)

Combine of sevoflurane and propofol

Group Type EXPERIMENTAL

combine of sevoflurane and propofol

Intervention Type DRUG

anesthesia was maintained with a combine of propofol (1 μg/ml via target-controlled infusion) and sevoflurane (end-tidal concentration 0.7-1.0 minimum alveolar concentration)

Interventions

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Sevoflurane

anesthesia was maintained with sevoflurane (end-tidal concentration 1.0-1.5 minimum alveolar concentration)

Intervention Type DRUG

Propofol

anesthesia was maintained with propofol (2-4 μg/ml via target-controlled infusion)

Intervention Type DRUG

combine of sevoflurane and propofol

anesthesia was maintained with a combine of propofol (1 μg/ml via target-controlled infusion) and sevoflurane (end-tidal concentration 0.7-1.0 minimum alveolar concentration)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* male adults
* aged 18-80 yr
* undergoing elective OPCAB surgery containing left anterior descending artery bypass

Exclusion Criteria

* a previous unusual response to any of the experimental anesthetics
* severe cardiac dysrhythmias or ejection fraction below 30%
* hemodynamic instability
* previous surgical coronary artery repair
* anemia, abnormal leukocytes or coagulopathy
* severe hypertension
* severe hepatic (albumin\<30g,ascites), renal (serum creatinine greater than 2.0 mg/dl) or pulmonary (preoperative pulmonary function tests moderate-severe) dysfunctions
* concomitant surgical procedures and psychiatric disorders
* Insulin-dependent diabetics

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No