Benefits of Total Intravenous Anesthesia Compared With Inhaled Anesthesia in Cardiovascular Surgery

NCT ID: NCT03233815

Last Updated: 2020-08-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-11-13

Study Completion Date

2021-12-31

Brief Summary

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This study compares the difference in proinflammatory markers Interleukin 6 (IL-6), Tumor necrosis factor alpha (TNFα) and cortisol in patients undergoing cardiovascular surgery to asses if there is a benefit of using intravenous total anesthesia (TIVA) over inhaled anesthesia for this procedures.

Detailed Description

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IL-6, TNFα and cortisol will be measure at the beginning of the cardiovascular surgery and 20 minutes after the cardiovascular bypass ends to calculate the difference between them and compare if there is any statistical difference between the proinflammatory markers with the two anesthesia techniques.

Conditions

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Cardiovascular Surgical Procedure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Inhaled anesthesia (Sevoflurane)

Patients undergoing cardiovascular surgery with inhaled anesthesia with sevoflurane.

Sevoflurane

Intervention Type DRUG

Inhaled anesthesia with sevoflurane. Dose: 1-2.5 Minimum Alveolar Concentration(MAC)

Total Intravenous Anesthesia (Propofol)

Patients undergoing cardiovascular surgery with total intravenous anesthesia with propofol.

Propofol

Intervention Type DRUG

Propofol anesthesia Dose: 4-6mg/kg/h

Interventions

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Propofol

Propofol anesthesia Dose: 4-6mg/kg/h

Intervention Type DRUG

Sevoflurane

Inhaled anesthesia with sevoflurane. Dose: 1-2.5 Minimum Alveolar Concentration(MAC)

Intervention Type DRUG

Other Intervention Names

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Diprivan Sevorane

Eligibility Criteria

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Inclusion Criteria

Scheduled for cardiovascular surgery American Society of Anaesthesiologists (ASA) physical status classification II-IV BMI \< 25 HbA1c \< 7%

Exclusion Criteria

Diabetic patients Known allergy to propofol
Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Coordinación de Investigación en Salud, Mexico

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ana Gallardo, PhD

Role: PRINCIPAL_INVESTIGATOR

Instituto Mexicano del Seguroa Social

Locations

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Hospital de cardiología

Mexico City, Mexico City, Mexico

Site Status

Countries

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Mexico

Other Identifiers

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R-2017-3604-95

Identifier Type: -

Identifier Source: org_study_id

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