Study to Examine the Effects of ATP Supplementation on Muscle Excitability and Reaction Time During and Following a Repeated Sprint Bout

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

42 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-07-31

Study Completion Date

2015-08-31

Brief Summary

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We hypothesize that adenosine-5'-triphosphate (ATP) supplementation will be able to enhance motor unit recruitment while simultaneously blunting the decline in power and reaction time that is typically seen during repetitive sprints. This will give researchers a better understanding of the mechanism by which ATP supplementation can augment power, especially under high fatiguing conditions.

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Detailed Description

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Healthy participants of similar training status as previously tested will be enrolled into the study. The participants will be randomly assigned to either placebo supplementation or to 400 mg ATP per day for 14 days. The supplements will be taken in the morning and the last dose will be taken 30 min prior to testing on the last day. Testing will be performed at baseline and after the 14 days of supplementation. Ten successive sprints will be conducted on the Wingate apparatus as this has been previously demonstrated to decrease muscle excitability. After the sprints, muscle excitability, reaction time, and vertical jump power will be measured. In addition a blood sample will be obtained before and after supplementation and complete blood hematology and chemistry analyses will be performed. It is expected that ATP supplementation may help maintain muscle excitability and power after the successive sprint sessions.

Conditions

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Muscle Fatigue Caused by Repetitive Muscle Exercise

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Placebo

This arm will serve as the placebo supplementation.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DIETARY_SUPPLEMENT

ATP

This arm will serve as the treatment intervention, ATP

Group Type ACTIVE_COMPARATOR

ATP

Intervention Type DIETARY_SUPPLEMENT

400 mg of ATP

Interventions

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Placebo

Intervention Type DIETARY_SUPPLEMENT

ATP

400 mg of ATP

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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Placebo Comparator Peak ATP

Eligibility Criteria

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Inclusion Criteria

* Agree to eating a diet approved by a registered dietician consisting of the following by caloric percentages: 15-20% protein, 44-55% carbohydrate, and 25-30% fat.
* Must not have taken performance enhancing supplements for at least 3 months prior to the study start,
* Must be a non-smoker.
* Must not be taking amino acid supplements.
* Must not be using anabolic or catabolic hormones.
* Must not be taking any medications known to influence variables to be measured in the study.

Exclusion Criteria

* Will not agree to eating a diet approved by a registered dietician consisting of the following by caloric percentages: 15-20% protein, 44-55% carbohydrate, and 25-30% fat.
* Has taken performance enhancing supplements for at least 3 months prior to the study start,
* Is currently a non-smoker.
* Is currently taking amino acid supplements.
* Is currently using anabolic or catabolic hormones.
* Is currently taking medications known to influence variables to be measured in the study.

Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes