Nutraceutical Support of Fatigue Reduction, Improved Physical, Mental & Cognitive Function and Mitochondrial Function

NCT ID: NCT04261881

Last Updated: 2020-04-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-03-27

Study Completion Date

2020-04-08

Brief Summary

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The purpose for this protocol is to perform an open-label human clinical pilot study on the effects of consumption of two nutraceutical blends in subjects with long-term unexplained fatigue interfering with daily living.

Detailed Description

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This is an open-label human clinical study to evaluate the effects of consumption of the nutraceutical product ATP-Fuel, compared to the nutraceutical product ATP-II. The study participants will be randomized to one of three groups: consuming ATP-Fuel (5 capsules, twice daily); consuming ATP-II (3 capsules, once daily); or consuming ATP-II (3 capsules, twice daily). The study is of 8 weeks' duration, with evaluation at baseline, 1, 4, and 8 weeks of product consumption.

At each visit the following measurements and procedures are performed: Blood pressure, questionnaires pertaining to fatigue, pain and wellness, and a blood draw. The blood is used for testing of lipid peroxidation and mitochondrial volume and metabolic activity.

Conditions

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Fatigue

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Nutraceutical intervention, 5 capsules twice daily.

Participants will consume the nutraceutical blend ATP-Fuel at 5 capsules twice daily.

Group Type ACTIVE_COMPARATOR

ATP-Fuel

Intervention Type DIETARY_SUPPLEMENT

5 capsules daily with breakfast and 5 capsules daily with lunch

Nutraceutical intervention, 3 capsules once daily.

Participants will consume the nutraceutical blend ATP-II at 3 capsules once daily.

Group Type ACTIVE_COMPARATOR

ATP-II

Intervention Type DIETARY_SUPPLEMENT

3 capsules daily with breakfast

Nutraceutical intervention, 3 capsules twice daily.

Participants will consume the nutraceutical blend ATP-II at 3 capsules twice daily.

Group Type ACTIVE_COMPARATOR

ATP-II

Intervention Type DIETARY_SUPPLEMENT

3 capsules daily with breakfast and 3 capsules daily with lunch

Interventions

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ATP-Fuel

5 capsules daily with breakfast and 5 capsules daily with lunch

Intervention Type DIETARY_SUPPLEMENT

ATP-II

3 capsules daily with breakfast

Intervention Type DIETARY_SUPPLEMENT

ATP-II

3 capsules daily with breakfast and 3 capsules daily with lunch

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Adult people of either gender;
* Age 18-75 years (inclusive);
* BMI between 18.0 and 34.9 (inclusive);
* Experiencing fatigue, at a level that moderately to severely interferes with daily activities, for the past 6 months.

Exclusion Criteria

* Cancer during past 12 months;
* Chemotherapy during past 12 months;
* Currently taking blood thinning medication (81mg aspirin allowed);
* Getting regular joint injections (such as cortisone shots);
* Have received a cortisone shot within past 12 weeks;
* Major surgery within the past 3 months;
* Major trauma within the past 3 months;
* Any other significant disease or disorder that the investigator judges may put the subject at risk because of participation in the study, or may influence the result of the study;
* Known food allergies or sensitivities related to the test products;
* Participation in another research study involving an investigational product in the past month;
* Planned surgery within 2 weeks of completing the study;
* Previous major surgery to stomach or intestines \[(absorption of test product may be altered) minor surgery is not a problem, including appendix and gallbladder removal\];
* Unwilling to maintain a constant intake of supplements over the duration of the study;
* Women who are pregnant, nursing, or trying to become pregnant.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Natural Immune Systems Inc

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Gitte Jensen, PhD

Role: PRINCIPAL_INVESTIGATOR

NIS Labs

Locations

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NIS Labs

Klamath Falls, Oregon, United States

Site Status

Countries

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United States

References

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Hamilton D, Jensen GS. Nutraceutical Support of Mitochondrial Function Associated With Reduction of Long-term Fatigue and Inflammation. Altern Ther Health Med. 2021 May;27(3):8-18.

Reference Type DERIVED
PMID: 33882028 (View on PubMed)

Other Identifiers

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NIS143-004

Identifier Type: -

Identifier Source: org_study_id

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