The Effect of Dietary Nitrate Supplementation on Linear Running Sprint Performance, Agility and Vertical Jump Performance in a Rested and Fatigued State

NCT ID: NCT03565523

Last Updated: 2018-06-21

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 32 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-09-01
• Study Completion Date: 2017-04-30

Brief Summary

Dietary nitrate (NO3-) supplementation has been shown to improve skeletal muscle contractility and fatigue resistance, particularly in fast-twitch (type II) muscle fibers. Furthermore, NO3- supplementation has been shown to speed reaction time. Taken together, these findings suggest that NO3- ingestion may be ergogenic during all-out sprint running and reactive agility tasks. Moreover, increasing muscle force production at high contraction speeds would be expected to translate into improved muscle power and, subsequently, improved performance in very explosive forms of exercise, such as vertical jumping. Therefore, the purpose of this investigation is to assess the effect of short term (5 days) NO3- supplementation on linear running sprint performance, reactive agility and vertical jump performance in a rested and fatigued state.

Conditions

Exercise Performance

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: DOUBLE

Study Groups

Test Beet shot

Containing 385 mg nitrate

Group Type: EXPERIMENTAL

Beetroot

Intervention Type: OTHER

Containing 385 mg nitrate

Placebo beverage

\<0.1 mmol nitrate in sucrose solution with beet coloring

Group Type: PLACEBO_COMPARATOR

Placebo beverage

Intervention Type: OTHER

\<0.1 mmol nitrate in sucrose solution with beet coloring

Interventions

Beetroot

Containing 385 mg nitrate

Intervention Type: OTHER

Placebo beverage

\<0.1 mmol nitrate in sucrose solution with beet coloring

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. Male and female participants in self-reported good general health as assessed by the standard procedures described below and specifically meeting normal blood pressure range (systolic: 100-135, diastolic: 60-90) and body mass index (BMI) range (16.0-29.9)

2. Range of 18-45 years of age

3. Participants must participate in an intermittent exercise based sport (e.g. soccer, rugby, hockey), at a competitive level (i.e. competes in officiated matches/games).

4. Understanding of the procedures to be undertaken as part of the study

5. Willingness to participate in exercise testing and follow supplementation guidelines and other instructions provided by the experimenter

6. Informed, voluntary, written consent to participate in the study

Exclusion Criteria

1. Known pulmonary, cardiovascular or metabolic disease

2. Food allergies including phenylketonurea (PKU)

3. Current regular use of any dietary supplement (excluding macronutrient based supplements) or previous use of any dietary supplement in the past 6 months that is known to have a lasting effect.

4. Blood donation within 3 months prior to the start of the study

5. Substance abuse within 2 years of the start of the study

6. Smoking

7. Any prescription and non-prescription medication which may impact saliva production (antidepressants, diuretics, analgesics, antihistamines, anti-hyper/hypo-tensives, anti-anxiety, appetite suppressants).

8. Current or previous use of phosphodiesterase 5 (PDE5) inhibitors.

9. Participation in another clinical trial within past 4 weeks.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

PepsiCo Global R&D

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Andy Jones, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Exeter, Sport and Health Sciences department

Other Identifiers

PEP-1607

Identifier Type: -

Identifier Source: org_study_id